ArticleBone2013
Adherent lipopolysaccharide inhibits the osseointegration of orthopedic implants by impairing osteoblast differentiation.
Article in Bone, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 59 citations in OpenAlex.
- Effect of antiplatelet and anticoagulant medications on implant survival: a long-term retrospective cohort study.Oral and maxillofacial surgery · 2025Article
- Manganese Oxide Nanozyme-Doped Diatom for Safe and Efficient Treatment of Peri-Implantitis.ACS applied materials & interfaces · 2022Article
- Staphylococcus aureus and Acinetobacter baumannii Inhibit Osseointegration of Orthopedic Implants.Infection and immunity · 2022Article
- Impact of tribocorrosion and titanium particles release on dental implant complications - A narrative review.The Japanese dental science review · 2021Review
- Berberine ameliorates the LPS-induced imbalance of osteogenic and adipogenic differentiation in rat bone marrow-derived mesenchymal stem cells.Molecular medicine reports · 2021Article
- Ibudilast Mitigates Delayed Bone Healing Caused by Lipopolysaccharide by Altering Osteoblast and Osteoclast Activity.International journal of molecular sciences · 2021Article
- The Impact of EBM-Manufactured Ti6Al4V ELI Alloy Surface Modifications on Cytotoxicity toward Eukaryotic Cells and Microbial Biofilm Formation.Materials (Basel, Switzerland) · 2020Article
- Impact of Bacterial Infections on Osteogenesis: Evidence From In Vivo Studies.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2019Review
- Adhesion Behaviour of Primary Human Osteoblasts and Fibroblasts on Polyether Ether Ketone Compared with Titanium under In Vitro Lipopolysaccharide Incubation.Materials (Basel, Switzerland) · 2019Article
- Periprosthetic Joint Infection Caused by Gram-Positive Versus Gram-Negative Bacteria: Lipopolysaccharide, but not Lipoteichoic Acid, Exerts Adverse Osteoclast-Mediated Effects on the Bone.Journal of clinical medicine · 2019Article
- Improving the Quality of Life of Patients With Medical Devices by a Timely Analysis of Adverse Events.Frontiers in medicine · 2019Article
- Successful and failed mini-implants: microbiological evaluation and quantification of bacterial endotoxin.Journal of applied oral science : revista FOB · 2018Article
- Human bone graft cytocompatibility with mesenchymal stromal cells is comparable after thermal sterilization and washing followed by γ-irradiation: anRegenerative biomaterials · 2018Article
- NF-κB decoy oligodeoxynucleotide mitigates wear particle-associated bone loss in the murine continuous infusion model.Acta biomaterialia · 2016Article
- Emperor's new clothes: Is particle disease really infected particle disease?Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2016Review
- Particle Disease: A Current Review of the Biological Mechanisms in Periprosthetic Osteolysis After Hip Arthroplasty.The open orthopaedics journal · 2016Article
- Immunomodulatory Peptide IDR-1018 Decreases Implant Infection and Preserves Osseointegration.Clinical orthopaedics and related research · 2015Article
- Machine oil inhibits the osseointegration of orthopaedic implants by impairing osteoblast attachment and spreading.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2015Article
- Effect of retinoic acid on the function of lipopolysaccharide-stimulated bone marrow stromal cells grown on titanium surfaces.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2015Article
- Do genetic susceptibility, Toll-like receptors, and pathogen-associated molecular patterns modulate the effects of wear?Clinical orthopaedics and related research · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Osseointegration is the process by which an orthopedic implant makes direct bone-to-implant contact and is crucial for the long-term function of the implant. Surface contaminants, such as bacterial debris and manufacturing residues, may remain on orthopedic implants after sterilization and impair osseointegration. For example, specific lots of implants that were associated with impaired osseointegration and high failure rates were discovered to have contaminants including bacterial debris. Therefore, the goals of this study were to determine if bacterial debris exists on sterile orthopedic implants and if adherent bacterial debris inhibits the osseointegration of orthopedic implants. We found that debris containing lipopolysaccharide (LPS) from Gram-negative bacteria exists on both sterile craniofacial implants and wrist implants. Levels of bacterial debris vary not only between different lots of implants but within an individual lot. Using our murine model of osseointegration, we found that ultrapure LPS adherent to the implants inhibited bone-to-implant contact and biomechanical pullout measures. Analysis of osseointegration in knock-out mice demonstrated that adherent LPS inhibited osseointegration by signaling through its primary receptor, Toll-like receptor 4, and not by signaling through Toll-like receptor 2. Ultrapure LPS adherent to titanium alloy discs had no detectable effect on early stages of MC3T3-E1 osteogenesis in vitro such as attachment, spreading or growth. However, later stages of osteogenic differentiation and mineralization were inhibited by adherent LPS. Thus, LPS may inhibit osseointegration in part through cell autonomous effects on osteoblasts. These results highlight bacterial debris as a type of surface contaminant that can impair the osseointegration of orthopedic implants.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.