ArticleJournal of applied physiology (Bethesda, Md. : 1985)2012
Bone metabolism and nutritional status during 30-day head-down-tilt bed rest.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed.
- Exercise attenuates bed rest-induced increases in insulin resistance while α-klotho increases in 55 to 65 year-old women and men.Scientific reports · 2025Trial
- Effects of short-term dry immersion on bone remodeling markers, insulin and adipokines.PloS one · 2017Trial
- Early-phase musculoskeletal adaptations to different levels of eccentric resistance after 8 weeks of lower body training.European journal of applied physiology · 2014Trial
- Personalization and Fortification of In-Space Manufactured Emulsified Beverages for Long-Term Space Travel.Comprehensive reviews in food science and food safety · 2026Review
- Effects of 14 days of head-down bed rest with or without exercise, and subsequent recovery on bone turnover, density and structure in older adults.Experimental physiology · 2026Article
- Regulation of Renal and Extrarenal Calcitriol Synthesis and Its Clinical Implications.International journal of molecular sciences · 2025Review
- The State of the Organs of the Female Reproductive System after a 5-Day "Dry" Immersion.International journal of molecular sciences · 2023Article
- Bone metabolism during strict head-down tilt bed rest and exposure to elevated levels of ambient CONPJ microgravity · 2022Article
- Remarkable Plasticity of Bone Iron Homeostasis in Hibernating Daurian Ground Squirrels (International journal of molecular sciences · 2022Article
- Article
- The effects of microgravity on bone structure and function.NPJ microgravity · 2022Review
- DI-5-Cuffs: Bone Remodelling and Associated Metabolism Markers in Humans After Five Days of Dry Immersion to Simulate Microgravity.Frontiers in physiology · 2022Article
- PTH 1-34 promoted bone formation by regulating iron metabolism in unloading-induced bone loss.Frontiers in endocrinology · 2022Article
- Basolateral Amygdala Mediates Central Mechanosensory Feedback of Musculoskeletal System.Frontiers in molecular neuroscience · 2022Article
- The combined effects of simulated microgravity and X-ray radiation on MC3T3-E1 cells and rat femurs.NPJ microgravity · 2021Article
- Calcium homeostasis during hibernation and in mechanical environments disrupting calcium homeostasis.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2020Review
- Relationship between melatonin and bone resorption rhythms in premenopausal women.Journal of bone and mineral metabolism · 2019Article
- A comparison of exercise interventions from bed rest studies for the prevention of musculoskeletal loss.NPJ microgravity · 2019Article
- Bone mineral density in osteoporotic patients with pyogenic vertebral osteomyelitis: effect of early versus late treatment for osteoporosis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018Observational
- Effects of Iron Overload and Oxidative Damage on the Musculoskeletal System in the Space Environment: Data from Spaceflights and Ground-Based Simulation Models.International journal of molecular sciences · 2018Review
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
6 authors.
Funding
Abstract
Bed rest studies provide an important tool for modeling physiological changes that occur during spaceflight. Markers of bone metabolism and nutritional status were evaluated in 12 subjects (8 men, 4 women; ages 25-49 yr) who participated in a 30-day -6° head-down-tilt diet-controlled bed rest study. Blood and urine samples were collected twice before, once a week during, and twice after bed rest. Data were analyzed using a mixed-effects linear regression with a priori contrasts comparing all days to the second week of the pre-bed rest acclimation period. During bed rest, all urinary markers of bone resorption increased ~20% (P < 0.001), and serum parathyroid hormone decreased ~25% (P < 0.001). Unlike longer (>60 days) bed rest studies, neither markers of oxidative damage nor iron status indexes changed over the 30 days of bed rest. Urinary oxalate excretion decreased ~20% during bed rest (P < 0.001) and correlated inversely with urinary calcium (R = -0.18, P < 0.02). These data provide a broad overview of the biochemistry associated with short-duration bed rest studies and provide an impetus for using shorter studies to save time and costs wherever possible. For some effects related to bone biochemistry, short-duration bed rest will fulfill the scientific requirements to simulate spaceflight, but other effects (antioxidants/oxidative damage, iron status) do not manifest until subjects are in bed longer, in which case longer studies or other analogs may be needed. Regardless, maximizing research funding and opportunities will be critical to enable the next steps in space exploration.
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Registered trials
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