ArticleAntimicrobial resistance and infection control2012
Utility of the first few100 approach during the 2009 influenza A(H1N1) pandemic in the Netherlands.
Article in Antimicrobial resistance and infection control, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- High Infection Secondary Attack Rates of Severe Acute Respiratory Syndrome Coronavirus 2 in Dutch Households Revealed by Dense Sampling.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Article
- Article
- Identification of the relative timing of infectiousness and symptom onset for outbreak control.Journal of theoretical biology · 2020Article
- Using Clinical Research Networks to Assess Severity of an Emerging Influenza Pandemic.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Observational
- Article
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Authors and funding
12 authors.
Funding
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Abstract
backgroundTo guide policy and control measures, decent scientific data are needed for a comprehensive assessment of epidemiological, clinical and virological characteristics of the First Few hundred (FF100) cases. We discuss the feasibility of the FF100 approach during the 2009 pandemic and the added value compared with alternative data sources available.
methodsThe pandemic preparedness plan enabled us to perform a case-control study, assessing patient characteristics and risk factors for experiencing symptomatic influenza A(H1N1)2009 infection and providing insight into transmission. We assessed to what extent timely and novel data were generated compared to other available data sources.
resultsIn May-December 2009, a total of 68 cases and 48 controls were included in the study. Underlying non-respiratory diseases were significantly more common among cases compared to controls, while a protective effect was found for frequent hand washing. Seroconversion was found for 7/30 controls (23%), and persisting high titers for 4/30 controls (13%). The labour-intensive study design resulted in slow and restricted recruitment.
conclusionsThe findings of our case-control study gave new insights in transmission risks and possible interventions for improved control. Nevertheless, the FF100 approach lacked timeliness and power due to limited recruitment. For future pandemics we suggest pooling data from several countries, to enable collecting sufficient data in a relatively short period.
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