Evidence map›Paper›PMID 22995215›Full record

ReviewBiochimica et biophysica acta2013

Catalytic mechanisms of complex II enzymes: a structural perspective.

T M Iverson

Abstract readReview
In one paragraph

Review in Biochimica et biophysica acta, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

  1. Article
  2. Flexibility and Hydration of the QJournal of chemical information and modeling · 2025
    Article
  3. Redox-Activated Proton Transfer through a Redundant Network in the QJournal of chemical information and modeling · 2025
    Article
  4. Review
  5. Review
  6. Article
  7. Complex II ambiguities-FADHThe Journal of biological chemistry · 2024
    Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Mitochondrial Structure and Bioenergetics in Normal and Disease Conditions.International journal of molecular sciences · 2021
    Review
  19. The roles of SDHAF2 and dicarboxylate in covalent flavinylation of SDHA, the human complex II flavoprotein.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

T M IversonDepartment of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232-6600, USA. tina.iverson@vanderbilt.edu

Funding

Structural Biology Facility CoreP30ES000267 · NIEHS · VANDERBILT UNIVERSITY · PI GUENGERICH, F PETER · 1985 to 2014
$20.3M
Complexities of complex II: A versatile architecture for respirationR01GM079419 · NIGMS · VANDERBILT UNIVERSITY · PI IVERSON, T M · 2007 to 2011
$1.3M
NIEHS NIH HHS P30 ES000267NIGMS NIH HHS GM079419NIGMS NIH HHS R01 GM079419
6 · The paper itself

Abstract

Over a decade has passed since the elucidation of the first X-ray crystal structure of any complex II homolog. In the intervening time, the structures of five additional integral-membrane complex II enzymes and three homologs of the soluble domain have been determined. These structures have provided a framework for the analysis of enzymological studies of complex II superfamily enzymes, and have contributed to detailed proposals for reaction mechanisms at each of the two enzyme active sites, which catalyze dicarboxylate and quinone oxidoreduction, respectively. This review focuses on how structural data have augmented our understanding of catalysis by the superfamily. This article is part of a Special Issue entitled: Respiratory complex II: Role in cellular physiology and disease.

Indexed as

BenzoquinonesBiocatalysisElectron Transport Complex IIFumaratesHumansKineticsModels, MolecularMolecular StructureProtein BindingProtein Structure, TertiaryProtein SubunitsSuccinatesBenzoquinonesElectron Transport Complex IIFumaratesProtein Subunitsquinonerespiratory complex IISuccinates

Identifiers

PMID22995215
PMCPMC3537904

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.