Trial reportJournal of neurotrauma2013
Divergent modulation of clinical measures of volitional and reflexive motor behaviors following serotonergic medications in human incomplete spinal cord injury.
Trial report in Journal of neurotrauma, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 22 citations in OpenAlex.
- Body System Effects of a Multi-Modal Training Program Targeting Chronic, Motor Complete Thoracic Spinal Cord Injury.Journal of neurotrauma · 2018Trial
- Effects of serotonergic medications on locomotor performance in humans with incomplete spinal cord injury.Journal of neurotrauma · 2014Trial
- Descending Brainstem Systems Contribute to Ankle Clonus in Humans with Spinal Cord Injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- TAAR5 Modulates Sensorimotor Recovery After Spinal Cord Injury.Biomedicines · 2026Article
- Impact of commonly administered drugs on the progression of spinal cord injury: a systematic review.Communications medicine · 2024Article
- Intrinsic motoneuron properties in typical human development.The Journal of physiology · 2024Article
- A single sequence of intermittent hypoxia does not alter stretch reflex excitability in able-bodied individuals.Experimental physiology · 2024Article
- Phase 1 Safety Trial of Autologous Human Schwann Cell Transplantation in Chronic Spinal Cord Injury.Journal of neurotrauma · 2022Article
- Early escitalopram administration as a preemptive treatment strategy against spasticity after contusive spinal cord injury in rats.Scientific reports · 2021Article
- Repeated and patterned stimulation of cutaneous reflex pathways amplifies spinal cord excitability.Journal of neurophysiology · 2020Article
- The serotonin reuptake blocker citalopram destabilizes fictive locomotor activity in salamander axial circuits through 5-HTJournal of neurophysiology · 2020Article
- Serotonergic Modulation of Locomotor Activity From Basal Vertebrates to Mammals.Frontiers in neural circuits · 2020Review
- Strategies to augment volitional and reflex function may improve locomotor capacity following incomplete spinal cord injury.Journal of neurophysiology · 2018Review
- Rehabilitation Strategies after Spinal Cord Injury: Inquiry into the Mechanisms of Success and Failure.Journal of neurotrauma · 2017Review
- High-Intensity Locomotor Exercise Increases Brain-Derived Neurotrophic Factor in Individuals with Incomplete Spinal Cord Injury.Journal of neurotrauma · 2017Article
- Serotonergic transmission after spinal cord injury.Journal of neural transmission (Vienna, Austria : 1996) · 2015Review
- Effect of fluoxetine on disease progression in a mouse model of ALS.Journal of neurophysiology · 2014Article
- Recovery of neuronal and network excitability after spinal cord injury and implications for spasticity.Frontiers in integrative neuroscience · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Incomplete spinal cord injury (SCI) can result in profound impairments in volitional strength and reflex excitability, which contribute to loss of function. Human and animal models suggest that disruption of endogenous monoaminergic input, particularly serotonin (5-HT), from supraspinal centers contributes to this impaired motor function following SCI. In the present study, we investigated the effects of 5-HT medications on motor function in individuals with chronic (>1 year) SCI. Clinical measures of strength, spasticity/spasms, and walking ability were assessed in 12 individuals with chronic incomplete SCI following acute administration of either 8 mg cyproheptadine, a 5-HT antagonist, or 10 mg escitalopram, a selective 5-HT reuptake inhibitor (SSRI), in a double-blinded, randomized, crossover fashion. Results indicated that 5-HT medications modulated both volitional and reflexive behaviors with little change in walking performance; 5-HT antagonist medications depressed clinical measures of strength and spasticity/spasms, whereas SSRIs augmented both strength and spasticity/spasms. These changes are consistent with the dysregulation of 5-HT sensitive spinal neurons following SCI. This understanding may augment clinicians' awareness of the motor consequences of 5-HT medications.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.