SynthesisBMC infectious diseases2012
Role of Helicobacter pylori cagA EPIYA motif and vacA genotypes for the development of gastrointestinal diseases in Southeast Asian countries: a meta-analysis.
Synthesis in BMC infectious diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 3 of them syntheses that pooled it.
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Who cites it
53 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- CagA toxin and risk of Helicobacter pylori-infected gastric phenotype: A meta-analysis of observational studies.PloS one · 2024Pooled it
- Clinical relevance of the cagA and vacA s1m1 status and antibiotic resistance in Helicobacter pylori: a systematic review and meta-analysis.BMC infectious diseases · 2022Pooled it
- Association of Helicobacter pylori vacA genotypes and peptic ulcer in Iranian population: a systematic review and meta-analysis.BMC gastroenterology · 2020Pooled it
- Effects of periodontal therapy on eradication and recurrence of Helicobacter pylori infection after successful treatment.The Journal of international medical research · 2019Trial
- Review
- Genomic landscape and fine-scale population structure of Helicobacter pylori across China.Biomarker research · 2026Article
- Article
- Characteristics of Gastric Endoscopic and Histopathological Findings in the South and Southeast Asian Populations.JGH open : an open access journal of gastroenterology and hepatology · 2025Article
- Article
- Roles of the components of theFuture microbiology · 2024Review
- Virulence gene polymorphisms in Shandong Helicobacter pylori strains and their relevance to gastric cancer.PloS one · 2024Article
- Article
- Host Cell Antimicrobial Responses againstInternational journal of molecular sciences · 2022Review
- Article
- Seroepidemiological survey of the prevalence ofIJID regions · 2022Article
- Peptic Ulcer and Gastric Cancer: Is It All in the Complex Host-Microbiome Interplay That Is Encoded in the Genomes of "Us" and "Them"?Frontiers in microbiology · 2022Review
- EPIYA Motif Genetic Characterization fromAdvanced biomedical research · 2022Article
- Impact ofWorld journal of gastroenterology · 2021Review
- The endemic Helicobacter pylori population in Southern Vietnam has both South East Asian and European origins.Gut pathogens · 2021Article
- Overview ofGut and liver · 2021Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundInfection with cagA-positive, cagA EPIYA motif ABD type, and vacA s1, m1, and i1 genotype strains of Helicobacter pylori is associated with an exacerbated inflammatory response and increased risk of gastroduodenal diseases. However, it is unclear whether the prevalence and virulence factor genotypes found in Southeast Asia are similar to those in Western countries. Here, we examined the cagA status and prevalence of cagA EPIYA motifs and vacA genotypes among H. pylori strains found in Southeast Asia and examined their association with gastroduodenal disease.
methodsTo determine the cagA status, cagA EPIYA motifs, and vacA genotypes of H. pylori, we conducted meta-analyses of 13 previous reports for 1,281 H. pylori strains detected from several Southeast Asian countries.
resultsThe respective frequencies of cagA-positive and vacA s1, m1, and i1 genotypes among examined subjects were 93% (1,056/1,133), 98% (1,010/1,033), 58% (581/1,009), and 96% (248/259), respectively. Stratification showed significant variation in the frequencies of cagA status and vacA genotypes among countries and the individual races residing within each respective country. The frequency of the vacA m-region genotype in patients infected with East Asian-type strains differed significantly between the northern and southern areas of Vietnam (p < 0.001). Infection with vacA m1 type or cagA-positive strains was associated with an increased risk of peptic ulcer disease (odds ratio: 1.46, 95%CI: 1.01-2.12, p = 0.046 and 2.83, 1.50-5.34, p = 0.001, respectively) in the examined Southeast Asian populations.
conclusionsBoth Western- and East Asian-type strains of H. pylori are found in Southeast Asia and are predominantly cagA-positive and vacA s1 type. In Southeast Asia, patients infected with vacA m1 type or cagA-positive strains have an increased risk of peptic ulcer disease. Thus, testing for this genotype and the presence of cagA may have clinical usefulness.
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