Evidence map›Paper›PMID 22993687›Full record

ArticleScientific reports2012

A Polycomb complex remains bound through DNA replication in the absence of other eukaryotic proteins.

Bettina M Lengsfeld, Kayla N Berry, Sharmistha Ghosh, Masateru Takahashi, Nicole J Francis

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Role of chromatin in water stress responses in plants.Journal of experimental botany · 2014
    Review
  5. Review
  6. Asymmetric distribution of histones during Drosophila male germline stem cell asymmetric divisions.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2013
    Review
  7. Review
  8. Epigenetic programming and reprogramming during development.Nature structural & molecular biology · 2013
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Bettina M LengsfeldDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.
Kayla N Berry
Sharmistha Ghosh
Masateru Takahashi
Nicole J Francis
Harvard University · US

Funding

Biochemical dissection of epigenetic inheritance by Polycomb group proteins.R01GM078456 · NIGMS · HARVARD UNIVERSITY · PI FRANCIS, NICOLE JANE · 2006 to 2010
$2.0M
NIGMS NIH HHS GM078456-01NIGMS NIH HHS R01 GM078456
6 · The paper itself

Abstract

Propagation of chromatin states through DNA replication is central to epigenetic regulation and can involve recruitment of chromatin proteins to replicating chromatin through interactions with replication fork components. Here we show using a fully reconstituted T7 bacteriophage system that eukaryotic proteins are not required to tether the Polycomb complex PRC1 to templates during DNA replication. Instead, DNA binding by PRC1 can withstand passage of a simple replication fork.

Indexed as

DNA ReplicationBacteriophage T7Binding, CompetitiveDNA-Directed DNA PolymeraseDNA HelicasesDNA, ViralPlasmidsPolycomb-Group ProteinsProtein BindingViral ProteinsDNA-Directed DNA PolymeraseDNA HelicasesDNA, ViralPolycomb-Group ProteinsViral Proteins

Identifiers

PMID22993687
PMCPMC3443814
OpenAlexW2169631331

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.