ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Histamine release in the basal forebrain mediates cortical activation through cholinergic neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 58 citations in OpenAlex.
- From emotional arousal to executive action. Role of the prefrontal cortex.Brain structure & function · 2024Review
- Evaluation of eGFP expression in the ChAT-eGFP transgenic mouse brain.BMC neuroscience · 2023Article
- The Role of the Central Histaminergic System in Behavioral State Control.Current topics in behavioral neurosciences · 2022Review
- Effects of Prolonged Seizures on Basal Forebrain Cholinergic Neurons: Evidence and Potential Clinical Relevance.Neurotoxicity research · 2020Review
- Propofol Causes Consciousness Loss by Affecting GABA-A Receptor in the Nucleus Basalis of Rats.Behavioural neurology · 2020Article
- Increased Sensitivity of Mice Lacking Extrasynaptic δ-Containing GABAFrontiers in pharmacology · 2020Article
- Cortical Circuit Dysfunction as a Potential Driver of Amyotrophic Lateral Sclerosis.Frontiers in neuroscience · 2020Review
- Histamine HScientific reports · 2019Article
- Sleep and Microdialysis: An Experiment and a Systematic Review of Histamine and Several Amino Acids.Journal of circadian rhythms · 2019Article
- Article
- A Systematic Search and Mapping Review of Studies on Intracerebral Microdialysis of Amino Acids, and Systematized Review of Studies on Circadian Rhythms.Journal of circadian rhythms · 2018Review
- Sleep and Sedative States Induced by Targeting the Histamine and Noradrenergic Systems.Frontiers in neural circuits · 2018Review
- Hypothalamic Tuberomammillary Nucleus Neurons: Electrophysiological Diversity and Essential Role in Arousal Stability.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Article
- Article
- Histamine and the striatum.Neuropharmacology · 2016Review
- Hypothalamic L-Histidine Decarboxylase Is Up-Regulated During Chronic REM Sleep Deprivation of Rats.PloS one · 2016Article
- Region-Specific Dissociation between Cortical Noradrenaline Levels and the Sleep/Wake Cycle.Sleep · 2016Article
- TASK Channels on Basal Forebrain Cholinergic Neurons Modulate Electrocortical Signatures of Arousal by Histamine.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Cell assemblies of the basal forebrain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The basal forebrain (BF) is a key structure in regulating both cortical activity and sleep homeostasis. It receives input from all ascending arousal systems and is particularly highly innervated by histaminergic neurons. Previous studies clearly point to a role for histamine as a wake-promoting substance in the BF. We used in vivo microdialysis and pharmacological treatments in rats to study which electroencephalogram (EEG) spectral properties are associated with histamine-induced wakefulness and whether this wakefulness is followed by increased sleep and increased EEG delta power during sleep. We also investigated which BF neurons mediate histamine-induced cortical activation. Extracellular BF histamine levels rose immediately and remained constant throughout a 6 h period of sleep deprivation, returning to baseline levels immediately afterward. During the spontaneous sleep-wake cycle, we observed a strong correlation between wakefulness and extracellular histamine concentrations in the BF, which was unaffected by the time of day. The perfusion of histamine into the BF increased wakefulness and cortical activity without inducing recovery sleep. The perfusion of a histamine receptor 1 antagonist into the BF decreased both wakefulness and cortical activity. Lesioning the BF cholinergic neurons abolished these effects. Together, these results show that activation of the cholinergic BF by histamine is important in sustaining a high level of cortical activation, and that a lack of activation of the cholinergic BF by histamine may be important in initiating and maintaining nonrapid eye movement sleep. The level of histamine release is tightly connected to behavioral state, but conveys no information about sleep pressure.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.