Trial reportThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
In for a penny, in for a pound: methylphenidate reduces the inhibitory effect of high stakes on persistent risky choice.
Trial report in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Catecholaminergic modulation of trust decisions.Psychopharmacology · 2019Trial
- Waiting Impulsivity: The Influence of Acute Methylphenidate and Feedback.The international journal of neuropsychopharmacology · 2015Trial
- The cost of social punishment and high-lethality suicide attempts in the second half of life.Psychology and aging · 2014Trial
- Attenuated dynamic impulse control in risky action under the escalating risk and reward in gambling disorder.Psychological medicine · 2026Article
- Enhanced Risky Choice in Male Rats Elicited by the Acute Pharmacological Stressor Yohimbine Involves Prefrontal Dopamine D1 Receptor Activation.The international journal of neuropsychopharmacology · 2024Article
- Not so smart? "Smart" drugs increase the level but decrease the quality of cognitive effort.Science advances · 2023Article
- Toward a Unifying Account of Dopamine's Role in Cost-Benefit Decision Making.Biological psychiatry global open science · 2023Review
- When Helping Is Risky: The Behavioral and Neurobiological Trade-off of Social and Risk Preferences.Psychological science · 2021Article
- Noradrenergic Enhancement of Motor Learning, Attention, and Working Memory in Humans.The international journal of neuropsychopharmacology · 2021Article
- Shifting uncertainty intolerance: methylphenidate and attention-deficit hyperactivity disorder.Translational psychiatry · 2021Article
- Using pharmacological manipulations to study the role of dopamine in human reward functioning: A review of studies in healthy adults.Neuroscience and biobehavioral reviews · 2021Review
- Effects of 5-HTPsychopharmacology · 2020Article
- Using a dependent schedule to measure risky choice in male rats: Effects of d-amphetamine, methylphenidate, and methamphetamine.Experimental and clinical psychopharmacology · 2020Article
- The interplay between chasing behavior, time perspective, and gambling severity: An experimental study.Journal of behavioral addictions · 2019Article
- Dopamine and Gambling Disorder: Prospects for Personalized Treatment.Current addiction reports · 2019Article
- Alterations in functional brain networks associated with loss-chasing in gambling disorder and cocaine-use disorder.Drug and alcohol dependence · 2017Article
- MEG Signatures of a Perceived Match or Mismatch between Individual and Group Opinions.Frontiers in neuroscience · 2017Article
- Pathological choice: the neuroscience of gambling and gambling addiction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Review
- Systemic administration of 8-OH-DPAT and eticlopride, but not SCH23390, alters loss-chasing behavior in the rat.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Article
- Gambling rats and gambling addiction: reconciling the role of dopamine in irrationality.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
Abstract
Methylphenidate (MPH) is a stimulant that increases extracellular levels of dopamine and noradrenaline. It can diminish risky decision-making tendencies in certain clinical populations. MPH is also used, without license, by healthy adults, but the impact on their decision-making is not well established. Previous work has found that dopamine receptor activity of healthy adults can modulate the influence of stake magnitude on decisions to persistently gamble after incurring a loss. In this study, we tested for modulation of this effect by MPH in 40 healthy human adults. In a double-blind experiment, 20 subjects received 20 mg of MPH, while 20 matched controls received a placebo. All were provided with 30 rounds of opportunities to accept an incurred loss from their assets or opt for a "double-or-nothing" gamble that would either avoid or double it. Rounds began with a variable loss that would double with every failed gamble until it was accepted, recovered, or reached a specified maximum. Probability of recovery on any gamble was low and ambiguous. Subjects receiving placebo gambled less as the magnitude of the stake was raised and as the magnitude of accumulated loss escalated over the course of the task. In contrast, subjects treated with MPH gambled at a consistent rate, well above chance, across all stakes and trials. Trait reward responsiveness also reduced the impact of high stakes. The findings suggest that elevated catecholamine activity by MPH can disrupt inhibitory influences on persistent risky choice in healthy adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.