ArticleThe Journal of general virology2012
Hyperediting of human T-cell leukemia virus type 2 and simian T-cell leukemia virus type 3 by the dsRNA adenosine deaminase ADAR-1.
Article in The Journal of general virology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Host-mediated RNA editing in viruses.Biology direct · 2023Review
- ADAR Editing in Viruses: An Evolutionary Force to Reckon with.Genome biology and evolution · 2021Review
- Adenosine Deaminases Acting on RNA (ADARs) and Viral Infections.Annual review of virology · 2021Article
- Mutation Rates and Selection on Synonymous Mutations in SARS-CoV-2.Genome biology and evolution · 2021Article
- PCIP-seq: simultaneous sequencing of integrated viral genomes and their insertion sites with long reads.Genome biology · 2021Article
- Mutation rates and selection on synonymous mutations in SARS-CoV-2.bioRxiv : the preprint server for biology · 2021Article
- Spontaneous Mutations in HIV-1 Gag, Protease, RT p66 in the First Replication Cycle and How They Appear: Insights from an In Vitro Assay on Mutation Rates and Types.International journal of molecular sciences · 2020Article
- Evidence for host-dependent RNA editing in the transcriptome of SARS-CoV-2.Science advances · 2020Article
- Hypermutations in porcine respiratory and reproductive syndrome virus.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2019Article
- Equine infectious anemia virus in China.Oncotarget · 2018Review
- Rewriting the transcriptome: adenosine-to-inosine RNA editing by ADARs.Genome biology · 2017Review
- To translate, or not to translate: viral and host mRNA regulation by interferon-stimulated genes.Trends in cell biology · 2015Review
- ADAR1 enhances HTLV-1 and HTLV-2 replication through inhibition of PKR activity.Retrovirology · 2014Article
- Mutations in components of antiviral or microbial defense as a basis for breast cancer.Functional & integrative genomics · 2013Review
- HTLV-3/4 and simian foamy retroviruses in humans: discovery, epidemiology, cross-species transmission and molecular virology.Virology · 2013Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
RNA editing mediated by adenosine deaminases acting on RNA (ADARs) converts adenosine (A) to inosine (I) residues in dsRNA templates. While ADAR-1-mediated editing was essentially described for RNA viruses, the present work addresses the issue for two δ-retroviruses, human T-cell leukemia virus type 2 and simian T-cell leukemia virus type 3 (HTLV-2 and STLV-3). We examined whether ADAR-1 could edit HTLV-2 and STLV-3 virus genomes in cell culture and in vivo. Using a highly sensitive PCR-based method, referred to as 3DI-PCR, we showed that ADAR-1 could hypermutate adenosine residues in HTLV-2. STLV-3 hypermutation was obtained without using 3DI-PCR, suggesting a higher mutation frequency for this virus. Detailed analysis of the dinucleotide editing context showed preferences for 5' ArA and 5' UrA. In conclusion, the present observations demonstrate that ADAR-1 massively edits HTLV-2 and STLV-3 retroviruses in vitro, but probably remains a rare phenomenon in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.