ArticleAmerican journal of physiology. Renal physiology2012
In vivo Drosophilia genetic model for calcium oxalate nephrolithiasis.
Article in American journal of physiology. Renal physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 62 citations in OpenAlex.
- Review
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- XDH-1 inactivation causes xanthine stone formation inbioRxiv : the preprint server for biology · 2025Article
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- SLC26 family: a new insight for kidney stone disease.Frontiers in physiology · 2023Review
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- Drosophila melanogaster: a simple genetic model of kidney structure, function and disease.Nature reviews. Nephrology · 2022Review
- Transcriptional and functional motifs defining renal function revealed by single-nucleus RNA sequencing.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Review
- Updates on ion and water transport by the Malpighian tubule.Current opinion in insect science · 2021Review
- Transporters and tubule crystals in the insect Malpighian tubule.Current opinion in insect science · 2021Review
- Do calcium oxalate crystals protect against herbivory?Die Naturwissenschaften · 2021Article
- Physiological and Pathological Functions of SLC26A6.Frontiers in medicine · 2020Review
- Targeted renal knockdown of NaAmerican journal of physiology. Renal physiology · 2019Article
- The Drosophila Malpighian tubule as a model for mammalian tubule function.Current opinion in nephrology and hypertension · 2019Review
- A conserved role of the insulin-like signaling pathway in diet-dependent uric acid pathologies in Drosophila melanogaster.PLoS genetics · 2019Article
- Endocrine regulation of MFS2 by branchless controls phosphate excretion and stone formation in Drosophila renal tubules.Scientific reports · 2019Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Nephrolithiasis is a major public health problem with a complex and varied etiology. Most stones are composed of calcium oxalate (CaOx), with dietary excess a risk factor. Because of complexity of mammalian system, the details of stone formation remain to be understood. Here we have developed a nephrolithiasis model using the genetic model Drosophila melanogaster, which has a simple, transparent kidney tubule. Drosophilia reliably develops CaOx stones upon dietary oxalate supplementation, and the nucleation and growth of microliths can be viewed in real time. The Slc26 anion transporter dPrestin (Slc26a5/6) is strongly expressed in Drosophilia kidney, and biophysical analysis shows that it is a potent oxalate transporter. When dPrestin is knocked down by RNAi in fly kidney, formation of microliths is reduced, identifying dPrestin as a key player in oxalate excretion. CaOx stone formation is an ancient conserved process across >400 My of divergent evolution (fly and human), and from this study we can conclude that the fly is a good genetic model of nephrolithiasis.
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