ReviewPsychopharmacology2012
Modulation of nociception by social factors in rodents: contribution of the opioid system.
Review in Psychopharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 21 citations in OpenAlex.
- Homeostatic scaling of dynorphin signaling by a non-canonical opioid receptor.Nature communications · 2025Article
- Evidence that flocking behavior is rewarded by singing, flock mates, and mu opioid receptors in the nucleus accumbens.PloS one · 2025Article
- New Insights into Contradictory Changes in Brain-Derived Neurotrophic Factor (BDNF) in Rodent Models of Posttraumatic Stress Disorder (PTSD).Neurochemical research · 2024Review
- Current Status of Animal Models of Posttraumatic Stress Disorder: Behavioral and Biological Phenotypes, and Future Challenges in Improving Translation.Biological psychiatry · 2018Review
- Effects of environmental enrichment on self-administration of the short-acting opioid remifentanil in male rats.Psychopharmacology · 2017Article
- The effects of beta-endorphin: state change modification.Fluids and barriers of the CNS · 2015Review
- On the interaction between drugs of abuse and adolescent social behavior.Psychopharmacology · 2014Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleThe opioid system is involved in the regulation of several behavioral and physiological responses, controlling pain, reward, and addictive behaviors. Opioid administration, depending on drugs and doses, usually affects sociability reducing interactions between conspecifics, whereas some affiliative behaviors such as sexual activity, social grooming, and play behavior increase the endogenous opioid activity.
objectivesThe possible interaction between endogenous opioids released during socio/sexual behavior and their analgesic effect on pain response is reviewed in the rodent literature.
resultsDirect evidence for socially mediated opioid changes resulting in increase in nociceptive threshold derives from studies exploring the effects of defeat experiences, social isolation, maternal, sexual behavior, and social reunion among kin or familiar animals in laboratory rodents. Indirect evidence for endogenous activation of the opioid system, possibly affecting pain sensitivity, derives from studies investigating the relevance of natural social reward using the conditioned place preference protocols or analyzing ultrasonic vocalizations associated to positive affective contexts. Finally, genetic and epigenetic factors that affect the opioid system during development are reported to be involved in modulating the response to social stimuli as well as nociception.
conclusionsAll studies highlight the relevance of affiliative contact behavior between conspecifics that is responsible for the activation of the endogenous mu-opioid system, inducing nociceptive threshold increase.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.