ArticleJournal of the American Society for Mass Spectrometry2012
Dynamically harmonized FT-ICR cell with specially shaped electrodes for compensation of inhomogeneity of the magnetic field. Computer simulations of the electric field and ion motion dynamics.
Article in Journal of the American Society for Mass Spectrometry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Multiple ion isolation and accumulation events for selective chemical noise reduction and dynamic range enhancement in MALDI imaging mass spectrometry.The Analyst · 2024Article
- Radiolytically reworked Archean organic matter in a habitable deep ancient high-temperature brine.Nature communications · 2023Article
- FT-ICR Mass Spectrometry Imaging at Extreme Mass Resolving Power Using a Dynamically Harmonized ICR Cell with 1ω or 2ω Detection.Analytical chemistry · 2022Article
- Surface-induced Dissociation Mass Spectrometry as a Structural Biology Tool.Chemical reviews · 2022Review
- Evaluation of major historical ICR cell designs using electric field simulations.Mass spectrometry reviews · 2022Review
- Dynamic Range Expansion by Gas-Phase Ion Fractionation and Enrichment for Imaging Mass Spectrometry.Analytical chemistry · 2020Article
- Pushing the analytical limits: new insights into complex mixtures using mass spectra segments of constant ultrahigh resolving power.Chemical science · 2019Article
- Fourier Transform Ion Cyclotron Resonance Mass Spectrometry at the Cyclotron Frequency.Journal of the American Society for Mass Spectrometry · 2017Article
- Top-down Proteomics: Technology Advancements and Applications to Heart Diseases.Expert review of proteomics · 2016Review
- Oversampling Selective Accumulation Trapped Ion Mobility Spectrometry Coupled to FT-ICR MS: Fundamentals and Applications.Analytical chemistry · 2016Article
- Comprehensive analysis of tropomyosin isoforms in skeletal muscles by top-down proteomics.Journal of muscle research and cell motility · 2016Article
- The Role of Ultrahigh Resolution Fourier Transform Mass Spectrometry (FT-MS) in Astrobiology-Related Research: Analysis of Meteorites and Tholins.International journal of molecular sciences · 2016Article
- Developments in FTICR-MS and Its Potential for Body Fluid Signatures.International journal of molecular sciences · 2015Review
- Effective top-down LC/MS+ method for assessing actin isoforms as a potential cardiac disease marker.Analytical chemistry · 2015Article
- Three dimensional liquid chromatography coupling ion exchange chromatography/hydrophobic interaction chromatography/reverse phase chromatography for effective protein separation in top-down proteomics.Analytical chemistry · 2015Article
- Application of printed circuit board technology to FT-ICR MS analyzer cell construction and prototyping.Journal of the American Society for Mass Spectrometry · 2014Article
- Review
- Twelve million resolving power on 4.7 T Fourier transform ion cyclotron resonance instrument with dynamically harmonized cell--observation of fine structure in peptide mass spectra.Journal of the American Society for Mass Spectrometry · 2014Article
- From Supercomputer Modeling to Highest Mass Resolution in FT-ICR.Mass spectrometry (Tokyo, Japan) · 2013Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The recently introduced ion trap for FT-ICR mass spectrometers with dynamic harmonization showed the highest resolving power ever achieved both for ions with moderate masses 500-1000 Da (peptides) as well as ions with very high masses of up to 200 kDa (proteins). Such results were obtained for superconducting magnets of very high homogeneity of the magnetic field. For magnets with lower homogeneity, the time of transient duration would be smaller. In superconducting magnets used in FT-ICR mass spectrometry the inhomogeneity of the magnetic field in its axial direction prevails over the inhomogeneity in other directions and should be considered as the main factor influencing the synchronic motion of the ion cloud. The inhomogeneity leads to a dependence of the cyclotron frequency from the amplitude of axial oscillation in the potential well of the ion trap. As a consequence, ions in an ion cloud become dephased, which leads to signal attenuation and decrease in the resolving power. Ion cyclotron frequency is also affected by the radial component of the electric field. Hence, by appropriately adjusting the electric field one can compensate the inhomogeneity of the magnetic field and align the cyclotron frequency in the whole range of amplitudes of z-oscillations. A method of magnetic field inhomogeneity compensation in a dynamically harmonized FT-ICR cell is presented, based on adding of extra electrodes into the cell shaped in such a way that the averaged electric field created by these electrodes produces a counter force to the forces caused by the inhomogeneous magnetic field.
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