ArticleCell and tissue research2012
Cochlin expression in vestibular endorgans obtained from patients with Meniere's disease.
Article in Cell and tissue research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Morphological studies of labyrinthine tissue in patients affected with Meniere's disease and vestibular schwannoma following labyrinthectomy.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Article
- Anatomical and functional studies of vestibular neuroepithelia from patients with Ménière's disease.Disease models & mechanisms · 2025Article
- Review
- MiR-29a-deficiency causes thickening of the basilar membrane and age-related hearing loss by upregulating collagen IV and laminin.Frontiers in cellular neuroscience · 2023Article
- Article
- Advances in otolith-related protein research.Frontiers in neuroscience · 2022Review
- Personalized Proteomics for Precision Diagnostics in Hearing Loss: Disease-Specific Analysis of Human Perilymph by Mass Spectrometry.ACS omega · 2021Article
- Ciliopathy genes are required for apical secretion of Cochlin, an otolith crystallization factor.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Biomarkers for Inner Ear Disorders: Scoping Review on the Role of Biomarkers in Hearing and Balance Disorders.Diagnostics (Basel, Switzerland) · 2020Article
- Making the Case for Research on Disease-Modifying Treatments to Tackle Post-lingual Progressive Sensorineural Hearing Loss.Frontiers in neurology · 2020Article
- The Price of Immune Responses and the Role of Vitamin D in the Inner Ear.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2019Review
- Investigations of the Microvasculature of the Human Macula Utricle in Meniere's Disease.Frontiers in cellular neuroscience · 2019Article
- Immunohistochemical localization of Nrf2 in the human cochlea.Brain research · 2018Article
- Oxidative Stress in the Blood Labyrinthine Barrier in the Macula Utricle of Meniere's Disease Patients.Frontiers in physiology · 2018Article
- The blood labyrinthine barrier in the human normal and Meniere's disease macula utricle.Scientific reports · 2017Article
- Article
- Immunohistochemical techniques for the human inner ear.Histochemistry and cell biology · 2016Review
- The expression of glutamate aspartate transporter (GLAST) within the human cochlea and its distribution in various patient populations.Brain research · 2013Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
The distribution of cochlin and its associated basement membrane proteins (collagen IV, collagen II, laminin-β2, and nidogen-1) were evaluated in the vestibular endorgans of subjects with Meniere's disease and compared with normal specimens. Cochlin mRNA expression in vestibular endorgans from Meniere's disease specimens was also investigated. Specimens were obtained from patients who had Meniere's disease and who were undergoing ablative labyrinthectomy. Control specimens were obtained both from autopsy specimens with documented normal audiovestibular function and from patients undergoing labyrinthectomy for acoustic neuroma excision. In the normal control specimens, cochlin immunoreactivity was found evenly distributed in the stroma of the cristae ampullaris and maculae of the utricle. In Meniere's specimens, cochlin immunoreactivity was markedly increased; this was associated with an increase in cochlin mRNA expression as shown by real-time reverse transcription with the polymerase chain reaction. Collagen IV and laminin-β2 immunoreactivity was significantly decreased in Meniere's specimens. Nidogen-1 and collagen II immunoreactivity was unchanged in Meniere's specimens when compared with normal samples. Cochlin upregulation has been implicated in the hereditary audiovestibulopathy, DFNA9. The increased expression of cochlin and decreased expression of collagen IV and laminin in Meniere's disease are suggestive that the overexpression of cochlin contributes to the dysfunctional inner ear homeostasis seen in this disease.
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