ArticleParasitology research2013
Detection of toxoplasmosis in patients with end-stage renal disease by enzyme-linked immunosorbent assay and polymerase chain reaction methods.
Article in Parasitology research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- A systematic review and meta-analysis of the prevalence of toxoplasmosis in hemodialysis patients in Iran.Epidemiology and health · 2018Pooled it
- Latent Toxoplasma gondii infection and associated risk factors among patients with chronic kidney disease: a registry-based study.BMC nephrology · 2025Article
- Toxoplasma gondii molecular detection and phylogenetic analysis in hemodialysis patients from Khuzestan, Southwest Iran.Tropical medicine and health · 2024Article
- The Association ofMicroorganisms · 2022Article
- Detection of Acute and ChronicJournal of parasitology research · 2021Article
- Protective Immunity Induced by TgMIC5 and TgMIC16 DNA Vaccines Against Toxoplasmosis.Frontiers in cellular and infection microbiology · 2021Article
- Seroprevalence and associated risk factors of Toxoplasma gondii infection in patients undergoing hemodialysis and healthy group.BMC research notes · 2020Article
- Opportunistic parasitoses among Egyptian hemodialysis patients in relation to CD4+ T-cell counts: a comparative study.BMC infectious diseases · 2019Article
- GRA24-Based DNA Vaccine Prolongs Survival in Mice Challenged With a VirulentFrontiers in immunology · 2019Article
- Seroepidemiological evaluation ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2018Article
- The association between Toxoplasma gondii infection and hypertensive disorders in T2DM patients: a case-control study in the Han Chinese population.Parasitology research · 2018Article
- Calcium-dependent protein kinases are potential targets forClinical and experimental vaccine research · 2018Review
- Seroprevalence and molecular evaluation of toxoplasmosis in children with cancer in Khuzestan province, Southwest of Iran.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2017Article
- Detection and genotyping ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2017Article
- Seroprevalence of toxoplasmosis in diabetic pregnant women in southwestern of Iran.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2016Article
- Spread and genotype of Toxoplasma gondii in naturally infected alpine chamois (Rupicapra r. rupicapra).Parasitology research · 2016Article
- Autophagy activated by Toxoplasma gondii infection in turn facilitates Toxoplasma gondii proliferation.Parasitology research · 2014Article
- Parasites and chronic renal failure.Journal of renal injury prevention · 2014Review
- Evaluation ofIranian journal of parasitologyArticle
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Toxoplasmosis caused by Toxoplasma gondii is an opportunistic infection. In healthy individuals, the infection is largely asymptomatic, but in immunocompromised people the parasite can become widely disseminated, causing severe toxoplasmosis. In patients undergoing haemodialysis, the phagocytic process shows a highly significant impairment. Therefore, this study aimed to investigate toxoplasmosis in patients with end-stage renal disease (ESRD) undergoing haemodialysis in Ahvaz hospitals, southwest of Iran. A total of 280 patients and 100 healthy subjects participated in this study. The presence of serum IgM and IgG antibodies against T. gondii was detected by ELISA and the presence of Toxoplasma parasites in whole blood was evaluated by GRA6 PCR. Anti-T. gondii IgG antibodies were detected in 82 (29.3 %) haemodialysis patients and 26 (26 %) controls. In addition, anti-T. gondii IgM antibodies were detected in 7.9 % of patients and in 4 % of controls. For both the antibodies, the differences were statistically significant (P < 0.05). PCR was performed with DNA extracted from blood samples of all patients and controls. PCR gave positive results with four of the 280 blood samples from patients but none for the control blood samples. The results revealed a high percentage of positivity for Toxoplasma antibodies in patients with ESRD undergoing haemodialysis and also confirmed the parasite in whole blood, indicating disseminated infection in these patients. Patients undergoing dialysis have a higher rate of active infection with Toxoplasma likely due to reactivation of a chronic infection. Thus, parasitological examinations of ESRD patients should be periodically carried out for monitoring and evaluating the possible dissemination of toxoplasmosis during haemodialysis.
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