ArticleLab on a chip2012
Patterning microscale extracellular matrices to study endothelial and cancer cell interactions in vitro.
Article in Lab on a chip, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 49 citations in OpenAlex.
- Strategies to control cellular spatial organization in microphysiological systems.Microsystems & nanoengineering · 2026Review
- Review
- Bioengineering gradients for controlled embryo and organ modeling.Current opinion in biomedical engineering · 2025Article
- Engineering multifunctional surface topography to regulate multiple biological responses.Biomaterials · 2025Review
- Hyaluronic acid as a versatile building block for the development of biofunctional hydrogels: In vitro models and preclinical innovations.Materials today. Bio · 2025Article
- Advances in high throughput cell culture technologies for therapeutic screening and biological discovery applications.Bioengineering & translational medicine · 2024Review
- The Role of Microenvironmental Cues and Mechanical Loading Milieus in Breast Cancer Cell Progression and Metastasis.Frontiers in bioengineering and biotechnology · 2020Review
- Review
- Photo-immobilized EGF chemical gradients differentially impact breast cancer cell invasion and drug response in defined 3D hydrogels.Biomaterials · 2018Article
- Bioinspired Hydrogels to Engineer Cancer Microenvironments.Annual review of biomedical engineering · 2017Review
- A novel microfluidic 3D platform for culturing pancreatic ductal adenocarcinoma cells: comparison with in vitro cultures and in vivo xenografts.Scientific reports · 2017Article
- A Versatile Method of Patterning Proteins and Cells.Journal of visualized experiments : JoVE · 2017Article
- Controlled placement of multiple CNS cell populations to create complex neuronal cultures.PloS one · 2017Article
- A rapid co-culture stamping device for studying intercellular communication.Scientific reports · 2016Article
- Multiscale Cues Drive Collective Cell Migration.Scientific reports · 2016Article
- Progress towards understanding heterotypic interactions in multi-culture models of breast cancer.Integrative biology : quantitative biosciences from nano to macro · 2016Review
- A simple engineered platform reveals different modes of tumor-microenvironmental cell interaction.Biofabrication · 2015Article
- Hydrogels to model 3D in vitro microenvironment of tumor vascularization.Advanced drug delivery reviews · 2014Review
- Vacuum-assisted fluid flow in microchannels to pattern substrates and cells.Biofabrication · 2014Article
- TISSUE ENGINEERING PERFUSABLE CANCER MODELS.Current opinion in chemical engineering · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The extracellular matrix (ECM) of the tumor niche provides support to residing and migrating cells and presents instructive cues that influence cellular behaviours. The ECM protein fibronectin (Fn) enables vascular network formation, while hyaluronic acid (HA) is known to facilitate breast tumor development. To recapitulate aspects of the tumor microenvironment, we developed systems of spatially defined Fn and HA for the co-culture of endothelial colony forming cells (ECFCs) and breast cancer cells (BCCs). A micropatterned system was developed using sequential microcontact printing of HA and Fn. This approach supported the preferential adhesion of ECFCs to Fn, but did not support the preferential adhesion of BCCs to HA. Thus, we developed a microstructured analog to spatially organize BCC-laden HA micromolded hydrogels adjacent to ECFCs in fibrin hydrogels. These novel, miniaturized systems allow the analysis of the spatial and temporal mechanisms regulating tumor angiogenesis, and can be applied to mimic other microenvironments of healthy and diseased tissues.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.