ArticleAmerican journal of physiology. Cell physiology2012
Chronic hypoxia and VEGF differentially modulate abundance and organization of myosin heavy chain isoforms in fetal and adult ovine arteries.
Article in American journal of physiology. Cell physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 29 citations in OpenAlex.
- Elevated Risk of Stroke in Young Adults After Traumatic Brain Injury: A Nationwide Study of 1 Million Individuals.Journal of the American Heart Association · 2024Article
- Postnatal development alters functional compartmentalization of myosin light chain kinase in ovine carotid arteries.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- Abnormal development of cerebral arteries and veins in offspring of experimentally preeclamptic rats: Potential role in perinatal stroke.Mechanisms of ageing and development · 2021Article
- Maternal Undernutrition Modulates Neonatal Rat Cerebrovascular Structure, Function, and Vulnerability to Mild Hypoxic-Ischemic Injury via Corticosteroid-Dependent and -Independent Mechanisms.International journal of molecular sciences · 2021Article
- Prenatal metyrapone treatment modulates neonatal cerebrovascular structure, function, and vulnerability to mild hypoxic-ischemic injury.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Gestational Hypoxia and Programing of Lung Metabolism.Frontiers in physiology · 2019Review
- Fetal Cerebrovascular Maturation: Effects of Hypoxia.Seminars in pediatric neurology · 2018Review
- Gestational Hypoxia and Developmental Plasticity.Physiological reviews · 2018Review
- Imatinib attenuates cerebrovascular injury and phenotypic transformation after intracerebral hemorrhage in rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Article
- Chronic cerebrovascular dysfunction after traumatic brain injury.Journal of neuroscience research · 2016Review
- Vascular Endothelial Growth Factor as a Prognostic Parameter in Subjects with "Plateau Red Face".High altitude medicine & biology · 2015Article
- Role of the sympathetic autonomic nervous system in hypoxic remodeling of the fetal cerebral vasculature.Journal of cardiovascular pharmacology · 2015Review
- VEGF receptors mediate hypoxic remodeling of adult ovine carotid arteries.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Smooth muscle phenotype switching in blast traumatic brain injury-induced cerebral vasospasm.Translational stroke research · 2014Review
- Vascular neural network phenotypic transformation after traumatic injury: potential role in long-term sequelae.Translational stroke research · 2014Article
- Phenotypic transformation of smooth muscle in vasospasm after aneurysmal subarachnoid hemorrhage.Translational stroke research · 2014Review
- Maternal food restriction modulates cerebrovascular structure and contractility in adult rat offspring: effects of metyrapone.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Article
- The fetal cerebral circulation: three decades of exploration by the LLU Center for Perinatal Biology.Advances in experimental medicine and biology · 2014Article
- Molecular contributions to neurovascular unit dysfunctions after brain injuries: lessons for target-specific drug development.Future neurology · 2013Article
- Maturation and differentiation of the fetal vasculature.Clinical obstetrics and gynecology · 2013Review
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Chronic hypoxia increases vascular endothelial growth factor (VEGF) and thereby promotes angiogenesis. The present study explores the hypothesis that hypoxic increases in VEGF also remodel artery wall structure and contractility through phenotypic transformation of smooth muscle. Pregnant and nonpregnant ewes were maintained at sea level (normoxia) or 3,820 m (hypoxia) for the final 110 days of gestation. Common carotid arteries harvested from term fetal lambs and nonpregnant adults were denuded of endothelium and studied in vitro. Stretch-dependent contractile stresses were 32 and 77% of normoxic values in hypoxic fetal and adult arteries. Hypoxic hypocontractility was coupled with increased abundance of nonmuscle myosin heavy chain (NM-MHC) in fetal (+37%) and adult (+119%) arteries. Conversely, hypoxia decreased smooth muscle MHC (SM-MHC) abundance by 40% in fetal arteries but increased it 123% in adult arteries. Hypoxia decreased colocalization of NM-MHC with smooth muscle α-actin (SM-αA) in fetal arteries and decreased colocalization of SM-MHC with SM-αA in adult arteries. Organ culture with physiological concentrations (3 ng/ml) of VEGF-A(165) similarly depressed stretch-dependent stresses to 37 and 49% of control fetal and adult values. The VEGF receptor antagonist vatalanib ablated VEGF's effects in adult but not fetal arteries, suggesting age-dependent VEGF receptor signaling. VEGF replicated hypoxic decreases in colocalization of NM-MHC with SM-αA in fetal arteries and decreases in colocalization of SM-MHC with SM-αA in adult arteries. These results suggest that hypoxic increases in VEGF not only promote angiogenesis but may also help mediate hypoxic arterial remodeling through age-dependent changes in smooth muscle phenotype and contractility.
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