ArticleNeuroImage2012
Brain activation patterns during visual episodic memory processing among first-degree relatives of schizophrenia subjects.
Article in NeuroImage, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Temporal stability of functional network configurations and its relationship to cognition and psychopathology in early psychoses.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Maximum entropy model reveals frequent brain state switching in a multiversal brain function analysis in early psychoses.bioRxiv : the preprint server for biology · 2026Article
- From microstates to macroscales: A Critical Review of Maximum Entropy Modeling and Energy Landscape Analysis in functional MRI.Research square · 2025Article
- Multipronged investigation of morphometry and connectivity of hippocampal network in relation to risk for psychosis using ultrahigh field MRI.Schizophrenia research · 2023Article
- Thalamus Radiomics-Based Disease Identification and Prediction of Early Treatment Response for Schizophrenia.Frontiers in neuroscience · 2021Article
- Altered Brain Activation During Memory Retrieval Precedes and Predicts Conversion to Psychosis in Individuals at Clinical High Risk.Schizophrenia bulletin · 2019Article
- Changes in Resting-State Functional Connectivity of the Hippocampus Following Cognitive Effort Predict Memory Decline at Older Age-A Longitudinal fMRI Study.Frontiers in aging neuroscience · 2019Article
- Associative Memory Impairments Are Associated With Functional Alterations Within the Memory Network in Schizophrenia Patients and Their Unaffected First-Degree Relatives: An fMRI Study.Frontiers in psychiatry · 2019Article
- Neuropil contraction in relation to Complement C4 gene copy numbers in independent cohorts of adolescent-onset and young adult-onset schizophrenia patients-a pilot study.Translational psychiatry · 2018Article
- Aberrant perfusion and its connectivity within default mode network of first-episode drug-naïve schizophrenia patients and their unaffected first-degree relatives.Scientific reports · 2017Article
- Neuropil pruning in Early-Course Schizophrenia: Immunological, Clinical, and Neurocognitive Correlates.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2016Article
- Functional neuroanatomical correlates of episodic memory impairment in early phase psychosis.Brain imaging and behavior · 2016Article
- Anterior Cingulate Cortico-Hippocampal Dysconnectivity in Unaffected Relatives of Schizophrenia Patients: A Stochastic Dynamic Causal Modeling Study.Frontiers in human neuroscience · 2016Article
- Persistent infection by HSV-1 is associated with changes in functional architecture of iPSC-derived neurons and brain activation patterns underlying working memory performance.Schizophrenia bulletin · 2015Article
- White matter diffusivity and microarchitecture among schizophrenia subjects and first-degree relatives.Schizophrenia research · 2015Article
- Differential susceptibility of white matter tracts to inflammatory mediators in schizophrenia: an integrated DTI study.Schizophrenia research · 2015Article
- Memory deficits in schizophrenia: a selective review of functional magnetic resonance imaging (FMRI) studies.Behavioral sciences (Basel, Switzerland) · 2013Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Episodic memory deficits are proposed as a potential intermediate phenotype of schizophrenia. We examined deficits in visual episodic memory and associated brain activation differences among early course schizophrenia (n=22), first-degree relatives (n=16) and healthy controls without personal or family history of psychotic disorders (n=28). Study participants underwent functional magnetic resonance imaging on a 3T scanner while performing visual episodic memory encoding and retrieval task. We examined in-scanner behavioral performance evaluating response time and accuracy of performance. Whole-brain BOLD response differences were analyzed using SPM5 correcting for multiple comparisons. There was an incremental increase in response time among the study groups (healthy controls<first-degree relatives<schizophrenia) with no differences in accuracy for encoding. Response time for retrieval was significantly increased in schizophrenia subjects compared to healthy controls with no difference in accuracy. Although there were no significant differences in BOLD responses for the encoding task, we noted increased BOLD response to retrieval in the prefrontal regions (Brodmann areas 9 and 8), thalamus and insula among the schizophrenia subjects compared to healthy controls, and first-degree relatives. Familial risk for schizophrenia may be associated with qualitatively similar but quantitatively milder abnormalities in visual episodic memory retrieval but not for encoding in the prefrontal cortex and thalamus.
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Registered trials
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