Evidence map›Paper›PMID 22992469›Full record

ArticleKidney international2013

Chronic kidney disease alters intestinal microbial flora.

Nosratola D Vaziri, Jakk Wong, Madeleine Pahl, Yvette M Piceno, Jun Yuan, Todd Z DeSantis, Zhenmin Ni, Tien-Hung Nguyen, Gary L Andersen

7 registry-linked trialsOpen access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Kidney international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 7 registered trials, which are not on this map. Cited by 649 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
649citing papers in PubMed, 6 pooled it
14.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02929225 early_phase1completednot on this mapstarted 2016, after this paper: background citation

Effect of Probiotics on Modulating the Bacterial Translocation and Improving Micro-inflammation in Hemodialysis Patients

TypeinterventionalSponsorFirst Affiliated Hospital Xi'an Jiaotong UniversityRan2016 to 2018Enrolled50ConditionsKidney Failure, ChronicArmsBifid Triple Viable Capsules, placebo
NCT02976688 phase2 / phase3unknown statusnot on this mapstarted 2017, after this paper: background citation

Effects of Short-chain Fatty Acids, Here Sodium Propionate, a Metabolism Product of the Human Gut-microbiome, on Inflammatory and Metabolic Parameters in Patients on Maintenance Hemodialysis - a Pilot Study

TypeinterventionalSponsorAzienda Sanitaria ASL Avellino 2Ran2017 to 2017Enrolled15ConditionsEndstage Renal DiseaseArmsSodium Propionate
NCT03010696 completednot on this mapstarted 2015, after this paper: background citation

The Correlation Between Gut Microbiome/Metabolite and End Stage Renal Disease (ESRD)

TypeobservationalSponsorChina Agricultural UniversityRan2015 to 2017Enrolled293ConditionsKidney Failure, ChronicArmsNo interventions, questionnaire, collect specimen
NCT03010735 phase2 / phase3completednot on this mapstarted 2015, after this paper: background citation

Effects of Probiotics on Metabolism of Uremic Toxin in Patients With End Stage Renal Disease (ESRD)

TypeinterventionalSponsorChina Agricultural UniversityRan2015 to 2017Enrolled150ConditionsKidney Failure, ChronicArmsprobiotics, Placebo
NCT03877081 phase3unknown statusnot on this mapstarted 2019, after this paper: background citation

Effect of Probiotics and Prebiotics in Renal Function in Septic Acute Kidney Injury Patients, Randomized Control Trial

TypeinterventionalSponsorHospital Civil de GuadalajaraRan2019 to 2023Enrolled90ConditionsAcute Kidney Injury, Probiotics, SepsisArmsProbiotics, Placebo
NCT04361097 nacompletednot on this mapstarted 2018, after this paper: background citation

Fecal Microbiota Transplantation as a Therapeutic Strategy in the Progression of Chronic Kidney Disease

TypeinterventionalSponsorHospital Universitario Dr. Jose E. GonzalezRan2018 to 2020Enrolled28ConditionsChronic Kidney Disease Due to Hypertension, Chronic Kidney Disease Due to Type 2 Diabetes MellitusArmsFaecal microbiota transplant, Placebo
NCT06877585 completednot on this mapstarted 2025, after this paper: background citation

Association Between Fecal Microbiota Composition, Metabolite Concentrations, and Indoxyl Sulfate Levels in Hemodialysis Patients

Typeobservational_patient_registrySponsorTungs' Taichung Metroharbour HospitalRan2025 to 2025Enrolled58ConditionsDysbiosis
3 · Its place in the literature

Who cites it

649 citing papers in PubMed, 6 syntheses or guidelines pooled it, 1,121 citations in OpenAlex.

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589 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Nosratola D VaziriDivision of Nephrology and Hypertension, UC Irvine Medical Center, Irvine, California 92868, USA. ndvaziri@uci.edu
Jakk Wong
Madeleine Pahl
Yvette M Piceno
Jun Yuan
Todd Z DeSantis
Zhenmin Ni
Tien-Hung Nguyen
Gary L Andersen
Lawrence Berkeley National Laboratory · USUniversity of California, Irvine · USUniversity of California, Irvine Medical Center · USSecond Genome (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The population of microbes (microbiome) in the intestine is a symbiotic ecosystem conferring trophic and protective functions. Since the biochemical environment shapes the structure and function of the microbiome, we tested whether uremia and/or dietary and pharmacologic interventions in chronic kidney disease alters the microbiome. To identify different microbial populations, microbial DNA was isolated from the stools of 24 patients with end-stage renal disease (ESRD) and 12 healthy persons, and analyzed by phylogenetic microarray. There were marked differences in the abundance of 190 bacterial operational taxonomic units (OTUs) between the ESRD and control groups. OTUs from Brachybacterium, Catenibacterium, Enterobacteriaceae, Halomonadaceae, Moraxellaceae, Nesterenkonia, Polyangiaceae, Pseudomonadaceae, and Thiothrix families were markedly increased in patients with ESRD. To isolate the effect of uremia from inter-individual variations, comorbid conditions, and dietary and medicinal interventions, rats were studied 8 weeks post 5/6 nephrectomy or sham operation. This showed a significant difference in the abundance of 175 bacterial OTUs between the uremic and control animals, most notably as decreases in the Lactobacillaceae and Prevotellaceae families. Thus, uremia profoundly alters the composition of the gut microbiome. The biological impact of this phenomenon is unknown and awaits further investigation.

Indexed as

AdultAgedAnimalsBacteriaFecesFemaleHumansIntestinesKidney Failure, ChronicMaleMiddle AgedRatsRats, Sprague-DawleyUremia

Identifiers

PMID22992469
OpenAlexW2171060095

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

and 1 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.