ArticleJournal of translational medicine2012
Matrix metalloproteinase-dependent turnover of cartilage, synovial membrane, and connective tissue is elevated in rats with collagen induced arthritis.
Article in Journal of translational medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 41 citations in OpenAlex.
- Trial
- Serological biomarkers of joint tissue turnover predict tocilizumab response at baseline.Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases · 2014Trial
- Serum extracellular matrix biomarkers in rheumatoid arthritis, psoriatic arthritis and psoriasis and their association with hand function.Scientific reports · 2025Article
- Angiotensin ATFrontiers in immunology · 2022Article
- Article
- UP1306: A Composition Containing Standardized Extracts ofNutrients · 2019Article
- Tissue metabolite of type I collagen, C1M, and CRP predicts structural progression of rheumatoid arthritis.BMC rheumatology · 2019Article
- Article
- I-BET151 inhibits expression of RANKL, OPG, MMP3 and MMP9 in ankylosing spondylitisExperimental and therapeutic medicine · 2017Article
- miR-573 is a negative regulator in the pathogenesis of rheumatoid arthritis.Cellular & molecular immunology · 2016Article
- AAA-ATPase p97 suppresses apoptotic and autophagy-associated cell death in rheumatoid arthritis synovial fibroblasts.Oncotarget · 2016Article
- Inhibition of lysosomal protease cathepsin D reduces renal fibrosis in murine chronic kidney disease.Scientific reports · 2016Article
- Inflammation: Friend and Foe.EBioMedicine · 2015Article
- Arthritis induces early bone high turnover, structural degradation and mechanical weakness.PloS one · 2015Article
- Investigating the Robustness and Diagnostic Potential of Extracellular Matrix Remodelling Biomarkers in Alkaptonuria.JIMD reports · 2015Article
- Biglycan fragmentation in pathologies associated with extracellular matrix remodeling by matrix metalloproteinases.Fibrogenesis & tissue repair · 2013Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRheumatoid arthritis is a disease affecting the extracellular matrix of especially synovial joints. The thickness of the synovial membrane increases and surrounding tissue degrades, leading to altered collagen balance in the tissues. In this study, we investigated the altered tissue balance of cartilage, synovial membrane, and connective tissue in collagen induced arthritis (CIA) in rats.
methodsSix newly developed ELISAs quantifying MMP-derived collagen degradation (C1M, C2M, and C3M) and formation (P1NP, P2NP, and P3NP) was used to detect cartilage turnover in rats with CIA. Moreover, CTX-II was used to detect alternative type II collagen degradation and as control of the model. 10 Lewis rats were injected with porcrine type II collagen twice with a 7 day interval and 10 rats was injected with 0.05 M acetic acid as control. The experiment ran for 26 days.
resultsA significant increase in the degradation of type I, II, and III collagen (C1M, C2M, and C3M, respectively) was detected on day 22 (P = 0.0068, P = 0.0068, P < 0.0001, respectively), whereas no significant difference in formation (P1NP, P2NP, and P3NP) was detected at any time point (P=0.22, P=0.53, P=0.53, respectively). The CTX-II level increased strongly from disease onset and onwards.
conclusionA nearly total separation between diseased and control animals was detected with C3M, making it a good diagnostic marker. The balance of type I, II, and III collagen was significantly altered with CIA in rats, with favour of degradation of the investigated collagens. This indicates unbalanced turnover of the surrounding tissues of the synovial joints, leading to increased pain and degeneration of the synovial joints.
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