Trial reportNeuropharmacology2013
Genetic correlate of cognitive training response in schizophrenia.
Trial report in Neuropharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04040829 (Cognitive Remediation and Supported Education in Psychotic Disorders), which is not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Cognitive Remediation and Supported Education in Psychotic Disorders: a Randomized Controlled Trial on the Efficacy and the Best Predictors of Academic Functioning
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Video games for people with schizophrenia.The Cochrane database of systematic reviews · 2021Pooled it
- The effect of training intensity on implicit learning rates in schizophrenia.Scientific reports · 2021Trial
- Auditory versus visual neuroscience-informed cognitive training in schizophrenia: Effects on cognition, symptoms and quality of life.Schizophrenia research · 2020Trial
- Evidence for the contribution of COMT gene Val158/108Met polymorphism (rs4680) to working memory training-related prefrontal plasticity.Brain and behavior · 2020Trial
- Association between increased serum d-serine and cognitive gains induced by intensive cognitive training in schizophrenia.Schizophrenia research · 2019Trial
- COMT genotype and response to cognitive remediation in schizophrenia.Schizophrenia research · 2015Trial
- Ginkgo Biloba as a niche theme cognitive enhancer agent, 1420 dokumen of Scopus database. A bibliometric study from 1988 to 2024.F1000Research · 2025Article
- The moderating role of COMT gene rs4680 polymorphism between maladaptive metacognitive beliefs and negative symptoms in patients with schizophrenia.BMC psychiatry · 2024Article
- Auditory cognitive training improves prepulse inhibition in serine racemase mutant mice.Psychopharmacology · 2020Article
- A systematic review of moderators of cognitive remediation response for people with schizophrenia.Schizophrenia research. Cognition · 2020Review
- The role of genetics in cognitive remediation in schizophrenia: A systematic review.Schizophrenia research. Cognition · 2020Review
- Personalised treatment for cognitive dysfunction in individuals with schizophrenia spectrum disorders.Neuropsychological rehabilitation · 2018Article
- Cognitive Deficits in Schizophrenia: Understanding the Biological Correlates and Remediation Strategies.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2018Review
- The Moderating Role of COMT and BDNF Polymorphisms on Transfer Effects Following Multi- and Single-Domain Cognitive Training Among Community-Dwelling Shanghainese Older Adults.Frontiers in aging neuroscience · 2018Article
- Factors Associated With Response and Resistance to Cognitive Remediation in Schizophrenia: A Critical Review.Frontiers in pharmacology · 2018Review
- Cognitive training in mental disorders: update and future directions.The American journal of psychiatry · 2014Review
- Psychopharmacological treatment of neurocognitive deficits in people with schizophrenia: a review of old and new targets.CNS drugs · 2014Review
- Cognitive interventions targeting brain plasticity in the prodromal and early phases of schizophrenia.Annual review of clinical psychology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 2 countries.
Funding
Abstract
Intensive computerized auditory training results in improved cognition for schizophrenia patients, but participants show variation in their cognitive gains and the biological factors that affect the response to training are unknown. Single nucleotide polymorphisms (SNPs) in the catechol-O-methyltransferase (COMT) gene have been related to cognitive function. Here we asked if functional variation in this gene has an impact on the response of schizophrenia patients to cognitive training. We genotyped 48 schizophrenia patients who completed 50 h of computerized cognitive training and analyzed the association between DNA variants in the COMT gene and the improvement in global cognition. Although conventional analyses did not reveal any significant associations, a set-based analysis examining the aggregate effect of common variation in the COMT gene (42 SNPs) suggested association with improvement in global cognition. Eight SNPs, mostly located in the 3' end of the COMT gene, were nominally associated with improvement in cognition. These data suggest that genotype influences the response to intensive cognitive training in schizophrenia, and may indicate that cognitive training regimens need to be personalized to the underlying biosignatures of each individual patient. This article is part of a Special Issue entitled 'Cognitive Enhancers'.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.