Evidence map›Paper›PMID 22992296›Full record

Trial reportNicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco2013

Enhancing tobacco quitline effectiveness: identifying a superior pharmacotherapy adjuvant.

Stevens S Smith, Paula A Keller, Kate H Kobinsky, Timothy B Baker, David L Fraser, Terry Bush, Brooke Magnusson, Susan M Zbikowski, Timothy A McAfee, Michael C Fiore

2 registry-linked trialsOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 30 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 8 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01087905 phase4completednot on this map

Improving the Population-Wide Effectiveness of U.S. Tobacco Cessation Quitlines

TypeinterventionalSponsorUniversity of Wisconsin, MadisonRan2010 to 2011Enrolled987ConditionsSmoking, Smoking CessationArmsNicotine patch, Nicotine gum, CMAC
NCT03194958 nacompletednot on this mapstarted 2017, after this paper: background citation

Helping the Poor Quit Smoking: Specialized Quitlines and Meeting Basic Needs

TypeinterventionalSponsorWashington University School of MedicineRan2017 to 2022Enrolled1,944ConditionsSmoking Cessation, Smoking, Tobacco, Smoking, Cigarette, Smoking, PipeArmsSpecialized Quitline, Basic Needs Navigator
3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 8 syntheses or guidelines pooled it, 52 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Pooled it
  4. Interventions to increase adherence to medications for tobacco dependence.The Cochrane database of systematic reviews · 2019
    Pooled it
  5. Pooled it
  6. Telephone counselling for smoking cessation.The Cochrane database of systematic reviews · 2019
    Pooled it
  7. Pooled it
  8. Pooled it
  9. Trial
  10. Trial
  11. Trial
  12. Trial
  13. Trial
  14. Impact of a Smoking Cessation Quitline in Vietnam: Evidence Base and Future Directions.International journal of environmental research and public health · 2019
    Trial
  15. A Randomized Controlled Trial of an Optimized Smoking Treatment Delivered in Primary Care.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2018
    Trial
  16. Trial
  17. Trial
  18. Trial
  19. Evaluating the effect of access to free medication to quit smoking: a clinical trial testing the role of motivation.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2014
    Trial
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Stevens S SmithDepartment of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. sss@ctri.medicine.wisc.edu
Paula A Keller
Kate H Kobinsky
Timothy B Baker
David L Fraser
Terry Bush
Brooke Magnusson
Susan M Zbikowski
Timothy A McAfee
Michael C Fiore
Clermont Université · FRTobacco Research Institute · CNUniversity of Wisconsin–Madison · USCenters for Disease Control and Prevention · USClearWay Minnesota · USUniversity of Wisconsin Health · US

Funding

Improving the population-wide effectiveness of U.S. tobacco cessation quitlinesRC1CA144382 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI SMITH, STEVENS SHEPPARD · 2009 to 2010
$998k
Training in Translational Tobacco ScienceK05CA139871 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI BAKER, TIMOTHY B · 2008 to 2012
$850k
NCI NIH HHS 1RC1CA144382NCI NIH HHS K05 CA139871NCI NIH HHS K05CA139871NCI NIH HHS RC1 CA144382
6 · The paper itself

Abstract

introductionTelephone tobacco quitlines are effective and are widely used, with more than 500,000 U.S. callers in 2010. This study investigated the clinical effectiveness and cost-effectiveness of 3 different quitline enhancements: combination nicotine replacement therapy (NRT), longer duration of NRT, and counseling to increase NRT adherence.

methodsIn this study, 987 quitline callers were randomized to a combination of quitline treatments in a 2 × 2 × 2 factorial design: NRT duration (2 vs. 6 weeks), NRT type (nicotine patch only vs. patch plus nicotine gum), and standard 4-call counseling (SC) versus SC plus medication adherence counseling (MAC). The primary outcome was 7-day point-prevalence abstinence (PPA) at 6 months postquit in intention-to-treat (ITT) analyses.

resultsCombination NRT for 6 weeks yielded the highest 6-month PPA rate (51.6%) compared with 2 weeks of nicotine patch (38.4%), odds ratios [OR] = 1.71 (95% confidence interval [CI]:1.20-2.45). A similar result was found for 2 weeks of combination NRT (48.2%), OR = 1.49 (95% CI: 1.04-2.14) but not for 6 weeks of nicotine patch alone (46.2%), OR = 1.38 (95% CI: 0.96-1.97). The MAC intervention effect was nonsignificant. Cost analyses showed that the 2-week combination NRT group had the lowest cost per quit ($442 vs. $464 for 2-week patch only, $505 for 6-week patch only, and $675 for 6-week combination NRT).

conclusionsCombination NRT for 2 or 6 weeks increased 6-month abstinence rates by 10% and 13%, respectively, over rates produced by 2 weeks of nicotine patch when offered with quitline counseling. A 10% improvement would potentially yield an additional 50,000 quitters annually, assuming 500,000 callers to U.S. quitlines per year.

Indexed as

HotlinesAdultChewing GumCost-Benefit AnalysisCounselingFemaleHumansMaleMiddle AgedNicotinePatient ComplianceSmokingSmoking CessationTelephoneTime FactorsTobacco ProductsChewing GumNicotine

Identifiers

PMID22992296
PMCPMC3611992
OpenAlexW2133603728

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.