ArticleJournal of the American Chemical Society2012
Femtosecond conical intersection dynamics of tryptophan in proteins and validation of slowdown of hydration layer dynamics.
Article in Journal of the American Chemical Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Dynamic Equilibrium between the Fluorescent State of Tryptophan and Its Cation-Electron Ion Pair Governs Triplet State Population.Journal of the American Chemical Society · 2025Article
- CryoEM and crystal structure analyses reveal the indirect role played by Trp89 in glutamate dehydrogenase enzymatic reactions.The FEBS journal · 2025Article
- Environment-Driven Coherent Population Transfer Governs the Ultrafast Photophysics of Tryptophan.Journal of the American Chemical Society · 2022Article
- Slowdown of Water Dynamics from the Top to the Bottom of the GroEL Cavity.The journal of physical chemistry letters · 2021Article
- Ultrafast Fluorescence Spectroscopy via Upconversion and Its Applications in Biophysics.Molecules (Basel, Switzerland) · 2021Review
- Ultrafast Dynamics of Water-Protein Coupled Motions around the Surface of Eye Crystallin.Journal of the American Chemical Society · 2020Article
- Femtosecond Fluorescence Spectra of NADH in Solution: Ultrafast Solvation Dynamics.The journal of physical chemistry. B · 2020Article
- Water Dynamics in the Hydration Shells of Biomolecules.Chemical reviews · 2017Review
- Dynamics and mechanism of ultrafast water-protein interactions.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Picosecond fluorescence dynamics of tryptophan and 5-fluorotryptophan in monellin: slow water-protein relaxation unmasked.The journal of physical chemistry. B · 2015Article
- Picosecond-resolved fluorescence studies of substrate and cofactor-binding domain mutants in a thermophilic alcohol dehydrogenase uncover an extended network of communication.Journal of the American Chemical Society · 2014Article
- Article
- Charge invariant protein-water relaxation in GB1 via ultrafast tryptophan fluorescence.Journal of the American Chemical Society · 2014Article
- Direct probing of solvent accessibility and mobility at the binding interface of polymerase (Dpo4)-DNA complex.The journal of physical chemistry. A · 2013Article
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Authors and funding
4 authors.
Funding
Abstract
Water motion probed by intrinsic tryptophan shows the significant slowdown around protein surfaces, but it is unknown how the ultrafast internal conversion of two nearly degenerate states of Trp ((1)L(a) and (1)L(b)) affects the initial hydration in proteins. Here, we used a mini-protein with 10 different tryptophan locations one at a time through site-directed mutagenesis and extensively characterized the conversion dynamics of the two states. We observed all the conversion time scales in 40-80 fs by measurement of their anisotropy dynamics. This result is significant and shows no noticeable effect on the initial observed hydration dynamics and unambiguously validates the slowdown of hydration layer dynamics as shown here again in two mutant proteins.
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