ArticleInternational journal of vascular medicine2012
Effects of the intensity of leg isometric training on the vasculature of trained and untrained limbs and resting blood pressure in middle-aged men.
Article in International journal of vascular medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 4 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 4 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- Effects of isometric training based on the entire population on blood pressure regulation: systematic review and meta-analysis of randomized controlled trials.Frontiers in public health · 2026Pooled it
- The effectiveness and safety of isometric resistance training for adults with high blood pressure: a systematic review and meta-analysis.Hypertension research : official journal of the Japanese Society of Hypertension · 2021Pooled it
- Isometric handgrip exercise training reduces resting systolic blood pressure but does not interfere with diastolic blood pressure and heart rate variability in hypertensive subjects: a systematic review and meta-analysis of randomized clinical trials.Hypertension research : official journal of the Japanese Society of Hypertension · 2021Pooled it
- Isometric exercise training for blood pressure management: a systematic review and meta-analysis to optimize benefit.Hypertension research : official journal of the Japanese Society of Hypertension · 2016Pooled it
- Effects of a 4-Week Multi-Exercise Isometric Resistance Training Programme on Resting and Ambulatory Blood Pressure in Normotensive Adults.European journal of sport science · 2026Trial
- Post-isometric exercise hypotension occurs irrespective of muscle mass in adults with hypertension: A randomized clinical trial.Clinics (Sao Paulo, Brazil) · 2025Trial
- Home-based isometric exercise training induced reductions resting blood pressure.European journal of applied physiology · 2017Trial
- The efficacy of isometric resistance training utilizing handgrip exercise for blood pressure management: A randomized trial.Medicine · 2016Trial
- Effects of isometric handgrip training dose on resting blood pressure and resistance vessel endothelial function in normotensive women.European journal of applied physiology · 2013Trial
- The acute and chronic effects of local aerobic exercise on cardiovascular physiology.Experimental physiology · 2026Review
- Effects of the Intensity, Duration, and Muscle Mass of Isometric Handgrip Exercise on Neuromuscular Fatigue and Post-Exercise Blood Pressure Responses: A Crossover Study.Health science reports · 2026Article
- The relationship between resistance exercise and cardiometabolic health: a cross-sectional analysis of the 1970 British cohort study.Sport sciences for health · 2026Article
- Efficacy and moderators of isometric resistance training (IRT) on resting blood pressure among patients with pre- to established hypertension: a multilevel meta-review and regression analysis.BMC sports science, medicine & rehabilitation · 2025Article
- Post-Exercise Hypotension Induced by a Short Isometric Exercise Session Versus Combined Exercise in Hypertensive Patients with Ischemic Heart Disease: A Pilot Study.Journal of functional morphology and kinesiology · 2025Article
- Effect of isometric resistance exercise on blood pressure in normotensive adults: a systematic review of randomized clinical trials.Annals of translational medicine · 2025Review
- Isometric Exercise Training and Arterial Hypertension: An Updated Review.Sports medicine (Auckland, N.Z.) · 2024Review
- An evidence-based guide to the efficacy and safety of isometric resistance training in hypertension and clinical implications.Clinical hypertension · 2023Review
- Getting the best GRIP on blood pressure control: Investigating a cost-effective isometric handgrip alternative.Chronic illness · 2022Article
- Effect of Lower- versus Higher-Intensity Isometric Handgrip Training in Adults with Hypertension: A Randomized Controlled Trial.Journal of cardiovascular development and disease · 2022Article
- Effects of isometric leg training on ambulatory blood pressure and morning blood pressure surge in young normotensive men and women.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this study was to establish whether changes in resting blood pressure and the vasculature of trained and untrained limbs are dependent on training intensity, following isometric-leg training. Thirty middle-aged males undertook an 8 week training programme (4 × 2 min bilateral-leg isometric contractions 3 times per week). Two groups trained at either high (HI; 14%MVC) or low (LO; 8%MVC) intensity a third group (CON) acted as controls. All parameters were measured at baseline, 4-weeks and post-training. Resting SBP (-10.8 ± 7.9 mmHg), MAP (-4.7 ± 6.8 mmHg) and HR (-4.8 ± 5.9 b·min(-1)) fell significantly in the HI group post-training with concomitant significant increases in resting femoral mean artery diameter (FMAD; 1.0 ± 0.4 mm), femoral mean blood velocity (FMBV; 0.68 ± 0.83 cm·s(-1)), resting femoral artery blood flow (FABF; 82.06 ± 31.92 ml·min(-1)) and resting femoral vascular conductance (FVC, 45%). No significant changes occurred in any brachial artery measure nor in any parameters measured in the LO or CON groups. These findings show that training-induced reductions in resting blood pressure after isometric-leg training in healthy middle-aged men are associated with concomitant adaptations in the local vasculature, that appear to be dependent on training intensity and take place in the later stages of training.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.