ArticleClinical & developmental immunology2012
Transfer of maternal immunity to newborns of diabetic mothers.
Article in Clinical & developmental immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 59 citations in OpenAlex.
- Delayed maturation of the milk microbiome in women with type 1 diabetes.Diabetologia · 2026Article
- Impact of Maternal Diabetes in Pregnancy on Newborn IgG Antibody Repertoire and Infection Risk in the First 6 Months of Life.Diabetes care · 2026Article
- Gestational Diabetes Mellitus Alters Cytokine Profiles and Macrophage Polarization in Human Placenta.International journal of molecular sciences · 2025Article
- Enrichment of Low-Abundance and Low-Molecular-Weight Proteins in Human Milk Using Mass Spectrometry-Based Proteomics.ACS omega · 2025Article
- Influence of Maternal and Neonatal Factors on Transplacental Passive Immunity after Vaccination against COVID-19.Vaccines · 2024Article
- Correlation between Melatonin and Colostral Regulatory T Cells inBiomolecules · 2024Article
- Maternal provisions in type 1 diabetes: Evidence for both protective & pathogenic potential.Frontiers in immunology · 2023Review
- Review
- Gestational Diabetes Mellitus Changes Human Colostrum Immune Composition.Frontiers in immunology · 2022Article
- Lactoferrin and Immunoglobulin Concentrations in Milk of Gestational Diabetic Mothers.Nutrients · 2021Article
- Article
- Shigella-specific antibodies in the first year of life among Zambian infants: A longitudinal cohort study.PloS one · 2021Article
- Role of Human Milk Bioactives on Infants' Gut and Immune Health.Frontiers in immunology · 2021Review
- Maternal Immunization: Nature Meets Nurture.Frontiers in microbiology · 2020Review
- Melatonin Action on the Activity of Phagocytes from the Colostrum of Obese Women.Medicina (Kaunas, Lithuania) · 2019Article
- Reduced Transplacental Transfer of Antimalarial Antibodies in Kenyan HIV-Exposed Uninfected Infants.Open forum infectious diseases · 2019Article
- The Role of Maternally Acquired Antibody in Providing Protective Immunity Against Nontyphoidal Salmonella in Urban Vietnamese Infants: A Birth Cohort Study.The Journal of infectious diseases · 2019Article
- Human colostrum action against Giardia lamblia infection influenced by hormones and advanced maternal age.Parasitology research · 2018Article
- Review
- Factors Affecting the FcRn-Mediated Transplacental Transfer of Antibodies and Implications for Vaccination in Pregnancy.Frontiers in immunology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study was carried out with hyperglycemic pregnant women to investigate the transfer of antibody classes to newborns across the placenta or by colostrum and the functional activity of phagocytes in maternal blood, cord blood, and colostrum from diabetes mothers. Samples from maternal blood, cord blood, and colostrum were collected from 20 normoglycemic and 20 hyperglycemic pregnant women. We determined antibodies levels, superoxide release, phagocytosis and bactericidal activity of phagocytes. We demonstrated that IgG levels in cord blood were higher in the hyperglycemic group. IgA and IgM levels were higher in maternal than in cord blood samples. Plasma antibody levels were lower in hyper- than in normoglycemic women. The colostrum of diabetic mothers had lower IgA and IgG levels. Colostrum and maternal blood phagocytes when exposed to EPEC increased the superoxide release. Cord blood phagocytes of hyperglycemic group, independently of bacteria, had higher superoxide release. Colostrum and blood phagocytes from diabetic group exhibited some phagocytic and microbicidal activity in response to EPEC. Mononuclear phagocytes from cord blood had the lowest phagocytosis, and bactericidal activity for EPEC, regardless of glycemic status. These data showed that hyperglycemia altered IgG transfer across the placenta and decreases immunoglobulin levels in maternal blood and colostrum.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.