ArticleDevelopment (Cambridge, England)2012
Autonomy in specification of primordial germ cells and their passive translocation in the sea urchin.
Article in Development (Cambridge, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed.
- Unique metabolic regulation of micromeres contributes to gastrulation in the sea urchin embryo.Nature communications · 2025Article
- The journey of a generation: advances and promises in the study of primordial germ cell migration.Development (Cambridge, England) · 2024Article
- Genome-wide identification and spatiotemporal expression analysis of cadherin superfamily members in echinoderms.EvoDevo · 2023Article
- Micromere formation and its evolutionary implications in the sea urchin.Current topics in developmental biology · 2022Article
- Conditional specification of endomesoderm.Cells & development · 2021Review
- Early patterning of ABCB, ABCC, and ABCG transporters establishes unique territories of small molecule transport in embryonic mesoderm and endoderm.Developmental biology · 2021Article
- Rab35 regulates skeletogenesis and gastrulation by facilitating actin remodeling and vesicular trafficking.Cells & development · 2021Article
- Diversity of activator of G-protein signaling (AGS)-family proteins and their impact on asymmetric cell division across taxa.Developmental biology · 2020Review
- Evolutionary modification of AGS protein contributes to formation of micromeres in sea urchins.Nature communications · 2019Article
- Distinct transcriptional regulation of Nanos2 in the germ line and soma by the Wnt and delta/notch pathways.Developmental biology · 2019Article
- Methods to label, isolate, and image sea urchin small micromeres, the primordial germ cells (PGCs).Methods in cell biology · 2019Review
- Early development of the feeding larva of the sea urchin Heliocidaris tuberculata: role of the small micromeres.Development genes and evolution · 2019Article
- Nodal and BMP expression during the transition to pentamery in the sea urchin Heliocidaris erythrogramma: insights into patterning the enigmatic echinoderm body plan.BMC developmental biology · 2017Article
- Differential Nanos 2 protein stability results in selective germ cell accumulation in the sea urchin.Developmental biology · 2016Article
- The diversity of nanos expression in echinoderm embryos supports different mechanisms in germ cell specification.Evolution & development · 2016Article
- Germ Line Mechanics--And Unfinished Business.Current topics in developmental biology · 2016Review
- Developmental expression of "germline"- and "sex determination"-related genes in the ctenophore Mnemiopsis leidyi.EvoDevo · 2016Article
- Influence of cell polarity on early development of the sea urchin embryo.Developmental dynamics : an official publication of the American Association of Anatomists · 2015Article
- Deployment of a retinal determination gene network drives directed cell migration in the sea urchin embryo.eLife · 2015Article
- Essential elements for translation: the germline factor Vasa functions broadly in somatic cells.Development (Cambridge, England) · 2015Article
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2 authors.
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Abstract
The process of germ line determination involves many conserved genes, yet is highly variable. Echinoderms are positioned at the base of Deuterostomia and are crucial to understanding these evolutionary transitions, yet the mechanism of germ line specification is not known in any member of the phyla. Here we demonstrate that small micromeres (SMics), which are formed at the fifth cell division of the sea urchin embryo, illustrate many typical features of primordial germ cell (PGC) specification. SMics autonomously express germ line genes in isolated culture, including selective Vasa protein accumulation and transcriptional activation of nanos; their descendants are passively displaced towards the animal pole by secondary mesenchyme cells and the elongating archenteron during gastrulation; Cadherin (G form) has an important role in their development and clustering phenotype; and a left/right integration into the future adult anlagen appears to be controlled by a late developmental mechanism. These results suggest that sea urchin SMics share many more characteristics typical of PGCs than previously thought, and imply a more widely conserved system of germ line development among metazoans.
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