Trial reportCirculation. Heart failure2012
PhosphdiesteRasE-5 Inhibition to Improve CLinical Status and EXercise Capacity in Diastolic Heart Failure (RELAX) trial: rationale and design.
Registry-linked trialAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph
Trial report in Circulation. Heart failure, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03084679 (Characterization of Myocardial Interstitial Fibrosis and Cardiomyocyte Hypertrophy by Cardiac MRI In Heart Failure), which is not on this map. Cited by 71 papers.
0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Characterization of Myocardial Interstitial Fibrosis and Cardiomyocyte Hypertrophy by Cardiac MRI In Heart Failure: Implication on Early Remodeling and on the Transition to Heart Failure
Who cites it
71 citing papers in PubMed.
- Correlates of Plasma NT-proBNP/Cyclic GMP Ratio in Heart Failure With Preserved Ejection Fraction: An Analysis of the RELAX Trial.Journal of the American Heart Association · 2024Trial
- Phosphodiesterase 5 inhibitor sildenafil in patients with heart failure with preserved ejection fraction and combined pre- and postcapillary pulmonary hypertension: a randomized open-label pilot study.BMC cardiovascular disorders · 2020Trial
- Clinical, Demographic, and Imaging Correlates of Anemia in Heart Failure With Preserved Ejection Fraction (from the RELAX Trial).The American journal of cardiology · 2020Trial
- Sildenafil enhances central hemodynamic responses to exercise, but not V̇oJournal of applied physiology (Bethesda, Md. : 1985) · 2019Trial
- CYP3A4 genotype is associated with sildenafil concentrations in patients with heart failure with preserved ejection fraction.The pharmacogenomics journal · 2018Trial
- High-sensitivity C-reactive protein in heart failure with preserved ejection fraction.PloS one · 2018Trial
- Physical Activity and Prognosis in the TOPCAT Trial (Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist).Circulation · 2017Trial
- Impaired left ventricular global longitudinal strain in patients with heart failure with preserved ejection fraction: insights from the RELAX trial.European journal of heart failure · 2017Trial
- Suppression of Tumorigenicity 2 in Heart Failure With Preserved Ejection Fraction.Journal of the American Heart Association · 2017Trial
- Impaired Right Ventricular-Pulmonary Arterial Coupling and Effect of Sildenafil in Heart Failure With Preserved Ejection Fraction: An Ancillary Analysis From the Phosphodiesterase-5 Inhibition to Improve Clinical Status And Exercise Capacity in Diastolic Heart Failure (RELAX) Trial.Circulation. Heart failure · 2016Trial
- Effects of sildenafil on ventricular and vascular function in heart failure with preserved ejection fraction.Circulation. Heart failure · 2015Trial
- Galectin-3 in heart failure with preserved ejection fraction. A RELAX trial substudy (Phosphodiesterase-5 Inhibition to Improve Clinical Status and Exercise Capacity in Diastolic Heart Failure).JACC. Heart failure · 2015Trial
- Cardiovascular phenotype in HFpEF patients with or without diabetes: a RELAX trial ancillary study.Journal of the American College of Cardiology · 2014Trial
- Resting ventricular-vascular function and exercise capacity in heart failure with preserved ejection fraction: a RELAX trial ancillary study.Circulation. Heart failure · 2014Trial
- Effects of interleukin-1 blockade with anakinra on aerobic exercise capacity in patients with heart failure and preserved ejection fraction (from the D-HART pilot study).The American journal of cardiology · 2014Trial
- Impact of atrial fibrillation on exercise capacity in heart failure with preserved ejection fraction: a RELAX trial ancillary study.Circulation. Heart failure · 2014Trial
- Trial
- The NO Pathway as a Target in Patients with Stable and Advanced Heart Failure: An Additional Arrow in Our Quiver!Biomolecules · 2025Review
- Review
- The Heart Has Intrinsic Ketogenic Capacity that Mediates NADCirculation research · 2025Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Margaret M RedfieldDepartment of Medicine, Baylor College of Medicine, Houston, TX, USA. redfield.margaret@mayo.edu
Barry A Borlaug
Greg D Lewis
Selma F Mohammed
Marc J Semigran
Martin M Lewinter
Anita Deswal
Adrian F Hernandez
Kerry L Lee
Eugene Braunwald
Heart Failure Clinical Research Network
Funding
MAYO CLINIC CENTER FOR TRANSLATIONAL SCIENCE ACTIVITIESUL1RR024150 · NCRR · MAYO CLINIC ROCHESTER · PI RIZZA, ROBERT A. · 2006 to 2011
$66.4MHeart Failure Clinical Research Network Coordinating CenterU10HL084904 · NHLBI · DUKE UNIVERSITY · PI ANSTROM, KEVIN J, HERNANDEZ, ADRIAN · 2012 to 2018
$38.0MHeart Failure Clinical Research Network - DCCU01HL084904 · NHLBI · DUKE UNIVERSITY · PI LEE, KERRY L · 2006 to 2011
$19.8MCARDIOVASOLOGYT32HL007111 · NHLBI · MAYO CLINIC ROCHESTER · PI Barry A. Borlaug · 1985 to 2026
$8.7MPartners Heart Failure NetworkU01HL084877 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI STEVENSON, LYNNE W · 2006 to 2011
$2.9MHeart Failure Clinical Research Network - RCCU01HL084875 · NHLBI · DUKE UNIVERSITY · PI O'CONNOR, CHRISTOPHER M · 2006 to 2011
$2.6MMayo Heart Failure Regional Clinical CenterU01HL084907 · NHLBI · MAYO CLINIC ROCHESTER · PI REDFIELD, MARGARET M · 2006 to 2011
$2.4MThe Texas Medical Center Regional Coordinating Center for Heart FailureU01HL084890 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI DESWAL, ANITA · 2006 to 2011
$1.8MGene- and Cell-based therapies for LVAD patientsU01HL084889 · NHLBI · UNIVERSITY OF UTAH · PI BULL, DAVID ANDREW · 2006 to 2011
$1.8MNew England, New York and Quebec Regional Clinical CenterU01HL084899 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI LEWINTER, MARTIN M · 2006 to 2011
$1.6MTreatment of Diastolic Heart Failure via AAV-9 Mediated Gene TransferR01HL105418 · NHLBI · MAYO CLINIC ROCHESTER · PI REDFIELD, MARGARET M · 2012 to 2015
$1.5MThe Minnesota Heart Failure Consortium: A Regional Clinical CenterU01HL084861 · NHLBI · HENNEPIN HEALTHCARE RESEARCH INSTITUTE · PI GOLDSMITH, STEVEN ROBERT · 2006 to 2011
$1.5MNCRR NIH HHS UL1 RR024150NHLBI NIH HHS HL07111-83NHLBI NIH HHS HL084861NHLBI NIH HHS HL084875NHLBI NIH HHS HL084877NHLBI NIH HHS HL084889NHLBI NIH HHS HL084890NHLBI NIH HHS HL084891NHLBI NIH HHS HL084899NHLBI NIH HHS HL084904NHLBI NIH HHS HL084907NHLBI NIH HHS HL084931NHLBI NIH HHS R01 HL105418NHLBI NIH HHS T32 HL007111NHLBI NIH HHS U01 HL084861NHLBI NIH HHS U01 HL084875NHLBI NIH HHS U01 HL084877NHLBI NIH HHS U01 HL084889NHLBI NIH HHS U01 HL084890NHLBI NIH HHS U01 HL084891NHLBI NIH HHS U01 HL084899NHLBI NIH HHS U01 HL084904NHLBI NIH HHS U01 HL084907NHLBI NIH HHS U01 HL084931NHLBI NIH HHS U10 HL084904
Abstract
PubMed holds no abstract for this paper.
Indexed as
Research DesignCardiovascular AgentsDouble-Blind MethodEchocardiography, DopplerExercise TestExercise ToleranceHeart Failure, DiastolicHumansMagnetic Resonance ImagingOxygen ConsumptionPhosphodiesterase 5 InhibitorsPiperazinesPurinesRecovery of FunctionSildenafil CitrateSulfonesCardiovascular AgentsPhosphodiesterase 5 InhibitorsPiperazinesPurinesSildenafil CitrateSulfones
Identifiers
What OpenQuestion holds
Textmetadata
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Read underepoch 390
Registered trials
NCT03084679ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.