ArticleThe Plant cell2012
Subunit organization of a synechocystis hetero-oligomeric thylakoid FtsH complex involved in photosystem II repair.
Article in The Plant cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- A FtsH-Like Zinc Metalloprotease, OsFtsH1, Coordinates Chloroplast Development and Photosystem II Homeostasis in Rice.Rice (New York, N.Y.) · 2026Article
- The GreenCut protein TEF6 maintains photosystem II homeostasis under high light by stabilizing FtsH accumulation in Chlamydomonas reinhardtii.Plant communications · 2026Article
- Osmotic signaling governs sunscreen biosynthesis to safeguard desert cyanobacteria against desiccation.mLife · 2026Article
- Regulation of mixotrophy inMicrobiology (Reading, England) · 2026Article
- Chloroplast ATP-dependent metalloprotease FtsH5/VAR1 confers cold-stress tolerance through singlet oxygen and salicylic acid signaling.Plant communications · 2025Article
- Genome-wide identification and comprehensive analysis of the FtsH gene family in wheat.Molecular biology reports · 2025Article
- The biogenesis and maintenance of PSII: Recent advances and current challenges.The Plant cell · 2024Review
- The Role of FtsH Complexes in the Response to Abiotic Stress in Cyanobacteria.Plant & cell physiology · 2024Review
- Prochlorococcus marinus responses to light and oxygen.PloS one · 2024Article
- Silencing of PepperInternational journal of molecular sciences · 2023Article
- Absolute quantification of cellular levels of photosynthesis-related proteins in Synechocystis sp. PCC 6803.Photosynthesis research · 2023Article
- Chloroplast proteostasis: A story of birth, life, and death.Plant communications · 2023Review
- FtsH4 protease controls biogenesis of the PSII complex by dual regulation of high light-inducible proteins.Plant communications · 2023Article
- Structure of native photosystem II assembly intermediate fromFrontiers in plant science · 2023Article
- Proximity Labeling Facilitates Defining the Proteome Neighborhood of Photosystem II Oxygen Evolution Complex in a Model Cyanobacterium.Molecular & cellular proteomics : MCP · 2022Article
- Cytoplasmic molecular chaperones in Pseudomonas species.Journal of microbiology (Seoul, Korea) · 2022Review
- Article
- Recent Advances in Understanding the Structural and Functional Evolution of FtsH Proteases.Frontiers in plant science · 2022Review
- Dehydration-Induced DnaK2 Chaperone Is Involved in PSII Repair of a Desiccation-Tolerant Cyanobacterium.Plant physiology · 2020Article
- Depletion of the FtsH1/3 Proteolytic Complex Suppresses the Nutrient Stress Response in the CyanobacteriumThe Plant cell · 2019Article
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8 authors.
Funding
Abstract
FtsH metalloproteases are key components of the photosystem II (PSII) repair cycle, which operates to maintain photosynthetic activity in the light. Despite their physiological importance, the structure and subunit composition of thylakoid FtsH complexes remain uncertain. Mutagenesis has previously revealed that the four FtsH homologs encoded by the cyanobacterium Synechocystis sp PCC 6803 are functionally different: FtsH1 and FtsH3 are required for cell viability, whereas FtsH2 and FtsH4 are dispensable. To gain insights into FtsH2, which is involved in selective D1 protein degradation during PSII repair, we used a strain of Synechocystis 6803 expressing a glutathione S-transferase (GST)-tagged derivative (FtsH2-GST) to isolate FtsH2-containing complexes. Biochemical analysis revealed that FtsH2-GST forms a hetero-oligomeric complex with FtsH3. FtsH2 also interacts with FtsH3 in the wild-type strain, and a mutant depleted in FtsH3, like ftsH2(-) mutants, displays impaired D1 degradation. FtsH3 also forms a separate heterocomplex with FtsH1, thus explaining why FtsH3 is more important than FtsH2 for cell viability. We investigated the structure of the isolated FtsH2-GST/FtsH3 complex using transmission electron microscopy and single-particle analysis. The three-dimensional structural model obtained at a resolution of 26 Å revealed that the complex is hexameric and consists of alternating FtsH2/FtsH3 subunits.
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