ArticleHepatology (Baltimore, Md.)2013
Intestinal mucus-derived nanoparticle-mediated activation of Wnt/β-catenin signaling plays a role in induction of liver natural killer T cell anergy in mice.
Article in Hepatology (Baltimore, Md.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Wnt signaling - using the bloodstream to send a message.Cellular and molecular life sciences : CMLS · 2025Review
- High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance.Nature communications · 2021Article
- Exosome-mediated communication in the tumor microenvironment contributes to hepatocellular carcinoma development and progression.Journal of hematology & oncology · 2019Review
- Functions of the WNT Signaling Network in Shaping Host Responses to Infection.Frontiers in immunology · 2019Review
- Extracellular Vesicles as Conveyors of Membrane-Derived Bioactive Lipids in Immune System.International journal of molecular sciences · 2018Review
- Temporal Regulation of Natural Killer T Cell Interferon Gamma Responses by β-Catenin-Dependent and -Independent Wnt Signaling.Frontiers in immunology · 2018Article
- Extracellular vesicles in liver disease and potential as biomarkers and therapeutic targets.Nature reviews. Gastroenterology & hepatology · 2017Review
- Wnt Signaling: Role in Regulation of Haematopoiesis.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2016Review
- Hepatic sinusoids in liver injury, inflammation, and fibrosis: new pathophysiological insights.Journal of gastroenterology · 2016Review
- Wnt3a: functions and implications in cancer.Chinese journal of cancer · 2015Review
- Enterobacteria-secreted particles induce production of exosome-like S1P-containing particles by intestinal epithelium to drive Th17-mediated tumorigenesis.Nature communications · 2015Article
- Interspecies communication between plant and mouse gut host cells through edible plant derived exosome-like nanoparticles.Molecular nutrition & food research · 2014Article
- Tuberous sclerosis 1 promotes invariant NKT cell anergy and inhibits invariant NKT cell-mediated antitumor immunity.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Targeted drug delivery to intestinal macrophages by bioactive nanovesicles released from grapefruit.Molecular therapy : the journal of the American Society of Gene Therapy · 2014Article
- Natural killer T (NKT) cells in autoimmune hepatitis.Current opinion in immunology · 2013Review
- Exosomes in the pathogenesis, diagnostics and therapeutics of liver diseases.Journal of hepatology · 2013Review
- Exosome-like nanoparticles from intestinal mucosal cells carry prostaglandin E2 and suppress activation of liver NKT cells.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
Corrections and comments
- Erratum issued
Authors and funding
12 authors.
Funding
Abstract
unlabelledThe Wnt/β-catenin pathway has been known to play a role in induction of immune tolerance, but its role in the induction and maintenance of natural killer T (NKT) cell anergy is unknown. We found that activation of the Wnt pathways in the liver microenvironment is important for induction of NKT cell anergy. We identified a number of stimuli triggering Wnt/β-catenin pathway activation, including exogenous NKT cell activator, glycolipid α-GalCer, and endogenous prostaglandin E2 (PGE2). Glycolipid α-GalCer treatment of mice induced the expression of wnt3a and wnt5a in the liver and subsequently resulted in a liver microenvironment that induced NKT cell anergy to α-GalCer restimulation. We also found that circulating PGE2 carried by nanoparticles is stable, and that these nanoparticles are A33(+) . A33(+) is a marker of intestinal epithelial cells, which suggests that the nanoparticles are derived from the intestine. Mice treated with PGE2 associated with intestinal mucus-derived exosome-like nanoparticles (IDENs) induced NKT cell anergy. PGE2 treatment leads to activation of the Wnt/β-catenin pathway by inactivation of glycogen synthase kinase 3β of NKT cells. IDEN-associated PGE2 also induces NKT cell anergy through modification of the ability of dendritic cells to induce interleukin-12 and interferon-β in the context of both glycolipid presentation and Toll-like receptor-mediated pathways.
conclusionThese findings demonstrate that IDEN-associated PGE2 serves as an endogenous immune modulator between the liver and intestines and maintains liver NKT cell homeostasis. This finding has implications for development of NKT cell-based immunotherapies. (HEPATOLOGY 2013).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.