Evidence map›Paper›PMID 22991217›Full record

ArticleBMJ open2012

Medication intensification in diabetes in rural primary care: a cluster-randomised effectiveness trial.

Katherine L Billue, Monika M Safford, Amanda H Salanitro, Thomas K Houston, William Curry, Yongin Kim, Jeroan J Allison, Carlos A Estrada

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in BMJ open, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00403091 (Internet Intervention to Improve Rural Diabetes Care), which is not on this map. Cited by 11 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 5 pooled it
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00403091 nacompletednot on this map

Internet Intervention to Improve Rural Diabetes Care

TypeinterventionalSponsorUniversity of Alabama at BirminghamRan2005 to 2010Enrolled205ConditionsDiabetes Mellitus Type 2ArmsInternet Intervention, Control
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 5 syntheses or guidelines pooled it, 17 citations in OpenAlex.

  1. Audit and feedback: effects on professional practice.The Cochrane database of systematic reviews · 2025
    Pooled it
  2. Pooled it
  3. Systematic review and narrative synthesis of computerized audit and feedback systems in healthcare.Journal of the American Medical Informatics Association : JAMIA · 2022
    Pooled it
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  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Katherine L BillueThe University of Alabama at Birmingham, Birmingham, Alabama, USA.
Monika M Safford
Amanda H Salanitro
Thomas K Houston
William Curry
Yongin Kim
Jeroan J Allison
Carlos A Estrada
University of Alabama at Birmingham · USUniversity of Massachusetts Chan Medical School · USBirmingham VA Medical Center · USVA Tennessee Valley Healthcare System · US

Funding

Internet Intervention For Improving Rural Diabetes CareR18DK065001 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ESTRADA, CARLOS A · 2005 to 2008
$2.1M
Building Capacity for Cardiometabolic Outcomes ResearchK24HL111154 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI SAFFORD, MONIKA M · 2012 to 2015
$556k
NHLBI NIH HHS K24 HL111154NIDDK NIH HHS R18 DK065001
6 · The paper itself

Abstract

objectiveTo determine the effectiveness of a provider-based intervention to improve medication intensification among patients with diabetes.

designEffectiveness cluster-randomised trial. Baseline and follow-up cross-sections of diabetes physicians' patients.

settingEleven U.S. Southeastern states, 2006-2008.

participants205 Rural primary care physicians, 95 completed the study.

interventionMulticomponent interactive intervention including web-based continuing medical education (CME), performance feedback and quality improvement tools. PRIMARY OUTCOME MEASURES: Medication intensification, a dose increase of an existing medication or the addition of a new class of medication for glucose, blood pressure and lipids control on any of the three most recent office visits.

resultsOf 364 physicians attempting to register, 102 were randomised to the intervention and 103 to the control arms; 95 physicians (intervention, n=48; control, n=47) provided data on their 1182 of their patients at baseline (intervention, n=715; control, n=467) and 945 patients at follow-up (intervention, n=479; control, n=466). For A1c control, medication intensification increased in both groups (intervention, pre 26.4% vs post 32.6%, p=0.022; control, pre 24.8% vs post 31.1%, p=0.033) (intervention, adjusted OR (AOR) 1.37; 95% CI 1.06 to 1.76; control, AOR 1.41 (95% CI 1.06 to 1.89)); however, we observed no incremental benefit solely due to the intervention (group-by-time interaction, p=0.948). Among patients with the worst glucose control (A1c >9%), intensification increased in both groups (intervention, pre 34.8% vs post 62.5%, p=0.002; control, pre 35.7% vs post 61.4%, p=0.008).

conclusionsA wide-reach, low-intensity, web-based interactive multicomponent intervention had no significant incremental effect on medication intensification for control of glucose, blood pressure or lipids for patients with diabetes of physicians practising in the rural Southeastern USA.

trial registrationNCT00403091.

Identifiers

PMID22991217
PMCPMC3467590
OpenAlexW2129602937

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.