ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2013
An economic evaluation: Simulation of the cost-effectiveness and cost-utility of universal prevention strategies against osteoporosis-related fractures.
Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Prevalence of sarcopenia in COPD patients using AWGS criteria among Asian populations: a systematic review and meta-analysis.BMC pulmonary medicine · 2026Pooled it
- The neglected association between schizophrenia and bone fragility: a systematic review and meta-analyses.Translational psychiatry · 2024Pooled it
- Economic models of community-based falls prevention: a systematic review with subsequent commissioning and methodological recommendations.BMC health services research · 2022Pooled it
- Construction of a predictive model for osteoporosis risk in men: using the IOF 1-min osteoporosis test.Journal of orthopaedic surgery and research · 2023Article
- Osteoporosis screening using machine learning and electromagnetic waves.Scientific reports · 2023Article
- Systematic review and critical methodological appraisal of community-based falls prevention economic models.Cost effectiveness and resource allocation : C/E · 2022Review
- Protocol for the models of primary osteoporosis screening in men (MOPS) cluster randomized trial.Contemporary clinical trials · 2022Article
- Cost-effectiveness and budget impact of dolutegravir/lamivudine for treatment of human immunodeficiency virus (HIV-1) infection in the United States.Journal of managed care & specialty pharmacy · 2021Article
- Economic evaluation of vitamin D and calcium food fortification for fracture prevention in Germany.Public health nutrition · 2017Article
- A model-based cost-effectiveness analysis of osteoporosis screening and treatment strategy for postmenopausal Japanese women.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Article
- Screening for and treatment of osteoporosis: construction and validation of a state-transition microsimulation cost-effectiveness model.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015Article
- Evaluation of using composite HPV genotyping assay results to monitor human papillomavirus infection burden through simulation.BMC infectious diseases · 2015Article
- Redefining the Economics of Geriatric Orthopedics.Geriatric orthopaedic surgery & rehabilitation · 2014Article
- At least one cyclic teriparatide administration can be helpful to delay initial onset of a new osteoporotic vertebral compression fracture.Yonsei medical journal · 2014Article
- Study on the role of zoledronic acid in treatment of postmenopausal osteoporosis women.Pakistan journal of medical sciences · 2013Article
- Osteoporosis associated with antipsychotic treatment in schizophrenia.International journal of endocrinology · 2013Article
- Cost-Effectiveness of Pharmacological Treatments for Osteoporosis Consistent with the Revised Economic Evaluation Guidelines for Canada.MDM policy & practiceArticle
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13 authors.
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No grant is acknowledged in the PubMed record.
Abstract
A patient-level Markov decision model was used to simulate a virtual cohort of 500,000 women 40 years old and over, in relation to osteoporosis-related hip, clinical vertebral, and wrist bone fractures events. Sixteen different screening options of three main scenario groups were compared: (1) the status quo (no specific national prevention program); (2) a universal primary prevention program; and (3) a universal screening and treatment program based on the 10-year absolute risk of fracture. The outcomes measured were total directs costs from the perspective of the public health care system, number of fractures, and quality-adjusted life-years (QALYs). Results show that an option consisting of a program promoting physical activity and treatment if a fracture occurs is the most cost-effective (CE) (cost/fracture averted) alternative and also the only cost saving one, especially for women 40 to 64 years old. In women who are 65 years and over, bone mineral density (BMD)-based screening and treatment based on the 10-year absolute fracture risk calculated using a Canadian Association of Radiologists and Osteoporosis Canada (CAROC) tool is the best next alternative. In terms of cost-utility (CU), results were similar. For women less than 65 years old, a program promoting physical activity emerged as cost-saving but BMD-based screening with pharmacological treatment also emerged as an interesting alternative. In conclusion, a program promoting physical activity is the most CE and CU option for women 40 to 64 years old. BMD screening and pharmacological treatment might be considered a reasonable alternative for women 65 years old and over because at a healthcare capacity of $50,000 Canadian dollars ($CAD) for each additional fracture averted or for one QALY gained its probabilities of cost-effectiveness compared to the program promoting physical activity are 63% and 75%, respectively, which could be considered socially acceptable. Consideration of the indirect costs could change these findings.
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