ArticleJournal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology2012
Encephalopsin (OPN3) protein abundance in the adult mouse brain.
Article in Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 57 citations in OpenAlex.
- Transcranial bright light treatment via the ear canals in seasonal affective disorder: a randomized, double-blind dose-response study.BMC psychiatry · 2014Trial
- Validation of phiC31-mediated expression and functional knockout of Opn3 in the Opn3-phiC31o knock-in mouse.Eye and vision (London, England) · 2025Article
- Hypothalamic opsin 3 suppresses MC4R signaling and potentiates Kir7.1 to promote food consumption.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Male rat hypothalamic extraretinal photoreceptor Opsin3 is sensitive to osmotic stimuli and light.Journal of neuroendocrinology · 2024Article
- Deep Diversity: Extensive Variation in the Components of Complex Visual Systems across Animals.Cells · 2022Review
- Estimations of the weather effects on brain functions using functional MRI: A cautionary note.Human brain mapping · 2022Article
- Opsins outside the eye and the skin: a more complex scenario than originally thought for a classical light sensor.Cell and tissue research · 2021Review
- Central Nervous System Associated With Light Perception and Physiological Responses of Birds.Frontiers in physiology · 2021Article
- TMT-Opsins differentially modulate medaka brain function in a context-dependent manner.PLoS biology · 2021Article
- Adaptive Thermogenesis in Mice Is Enhanced by Opsin 3-Dependent Adipocyte Light Sensing.Cell reports · 2020Article
- Exposure to Artificial Light at Night and the Consequences for Flora, Fauna, and Ecosystems.Frontiers in neuroscience · 2020Review
- Human nonvisual opsin 3 regulates pigmentation of epidermal melanocytes through functional interaction with melanocortin 1 receptor.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Evidence for encephalopsin immunoreactivity in interneurones and striosomes of the monkey striatum.Experimental brain research · 2018Article
- Olfactory, Taste, and Photo Sensory Receptors in Non-sensory Organs: It Just Makes Sense.Frontiers in physiology · 2018Review
- Unconventional Roles of Opsins.Annual review of cell and developmental biology · 2017Review
- Co-expression of xenopsin and rhabdomeric opsin in photoreceptors bearing microvilli and cilia.eLife · 2017Article
- A ciliary opsin in the brain of a marine annelid zooplankton is ultraviolet-sensitive, and the sensitivity is tuned by a single amino acid residue.The Journal of biological chemistry · 2017Article
- Melanopsin Contributions to the Representation of Images in the Early Visual System.Current biology : CB · 2017Article
- Light entrainment of the murine intraocular pressure circadian rhythm utilizes non-local mechanisms.PloS one · 2017Article
- Neuroprotective Effects Against POCD by Photobiomodulation: Evidence from Assembly/Disassembly of the Cytoskeleton.Journal of experimental neuroscience · 2016Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Encephalopsin belongs to the family of extraretinal opsins having a putative role in CNS tissue photosensitivity. Encephalopsin mRNA has earlier been localized in rodent brains, but expression and localization of the protein has not yet been reported. In this study, we aimed to define encephalopsin protein abundance and localization in the rodent brain. The distribution and localization of encephalopsin protein in a mouse brain and selected peripheral tissues were analysed in ten mice, using Western blotting and immunohistochemistry. The specificity of immunoreaction was validated by primary antibody omitting and immunizing peptide blocking experiment. We found encephalopsin protein abundant in the mouse brain, but not in the periphery. Encephalopsin protein was present in neurons of the mouse cerebral cortex, paraventricular area, and cerebellar cells. Our results show that encephalopsin is expressed at the protein level in different brain areas of the mouse. Therefore, the suggested idea that encephalopsin plays a role in non-visual photic processes seems to be applicable. Evidently, further investigations are needed to find out the signalling mechanisms, and the potential physiological role of encephalopsin in phototransduction due to the changes in ambient light.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.