ArticleNature immunology2012
Maintaining system homeostasis: the third law of Newtonian immunology.
Article in Nature immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed.
- Circadian Disruption Exacerbates Innate Immune Responses by Modulating the Bistability of Pro-Inflammatory Signaling: A Dynamical Modeling Study.Biomedicines · 2026Article
- Decoding Immune Regulation: From Genetic Variation to Mechanism Through Single-Cell Genomics.Immune network · 2026Review
- Systemic skewing of peripheral blood leukocyte composition in neurofibromatosis type 1.Frontiers in immunology · 2026Article
- Heterogeneous immune recovery after viral response through a dynamical model of feedback-driven persistence and clearance.Frontiers in immunology · 2026Article
- LAIR1 prevents excess inflammatory tissue damage in Staphylococcus aureus skin infection and Cutaneous T-cell Lymphoma.JCI insight · 2025Article
- Biological and clinical implications of a model of surveillance immunity.The Journal of clinical investigation · 2025Review
- The quantum model of T-cell activation: Revisiting immune response theories.Scandinavian journal of immunology · 2024Article
- Review
- B cell-reactive triad of B cells, follicular helper and regulatory T cells at homeostasis.Cell research · 2024Article
- Negative prognostic behaviour of PD-L1 expression in tongue and larynx squamous cell carcinoma and its significant predictive power in combination with PD-1 expression on TILs.BMC immunology · 2024Article
- Controlled expression of avian pre-migratory fattening influences indices of innate immunity.Biology open · 2024Article
- What Exactly Is Inflammation (and What Is It Not?).International journal of molecular sciences · 2022Review
- How many ways can you die? Multiple biological deaths as a consequence of the multiple concepts of an organism.Theoretical medicine and bioethics · 2022Article
- Age as a risk factor in vasculitis.Seminars in immunopathology · 2022Review
- The evolution of powerful yet perilous immune systems.Trends in immunology · 2022Review
- Human leukocyte antigen class II gene diversity tunes antibody repertoires to common pathogens.Frontiers in immunology · 2022Article
- Single-cell RNA sequencing reveals the molecular features of peripheral blood immune cells in children, adults and centenarians.Frontiers in immunology · 2022Article
- Overview of the pathogenesis of COVID-19 (Review).Experimental and therapeutic medicine · 2021Review
- Correlation of sPD1 with Procalcitonin and C-Reactive Protein Levels in Patients with Sepsis.Cell journal · 2021Article
- Bacterial virulence plays a crucial role in MRSA sepsis.PLoS pathogens · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Because of the potent effector mechanisms of the immune system, the potential for self-destructive immune responses is especially high and many negative regulatory modalities exist to prevent excessive tissue damage. This Commentary places such regulatory mechanisms in the larger context of system organization on many scales. The sometimes counterintuitive nature of feedback control is discussed and a case is made for greater attention to quantitative spatiotemporal aspects of regulation, rather than limiting the discussion to the qualitative descriptions of pathways that dominate at present.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.