ReviewPflugers Archiv : European journal of physiology2013
Evolving concepts on regulation and function of renin in distal nephron.
Review in Pflugers Archiv : European journal of physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Autosomal dominant tubulointerstitial kidney disease: diagnosis, classification, and management--A KDIGO consensus report.Kidney international · 2015Guideline
- Genetic Susceptibility to Chronic Kidney Disease: Links, Risks and Management.International journal of nephrology and renovascular disease · 2023Review
- Hormone-Dependent Regulation of Renin and Effects on Prorenin Receptor Signaling in the Collecting Duct.Current hypertension reviews · 2022Article
- Genetic renal disease classification by hormonal axes.Pediatric nephrology (Berlin, Germany) · 2020Review
- PGELaboratory investigation; a journal of technical methods and pathology · 2018Article
- Renal tubular angiotensin converting enzyme is responsible for nitro-L-arginine methyl ester (L-NAME)-induced salt sensitivity.Kidney international · 2017Article
- Bradykinin/BPhysiological reports · 2017Article
- Renal Atp6ap2/(Pro)renin Receptor Is Required for Normal Vacuolar H+-ATPase Function but Not for the Renin-Angiotensin System.Journal of the American Society of Nephrology : JASN · 2016Article
- The Circadian Clock in the Regulation of Renal Rhythms.Journal of biological rhythms · 2015Review
- Salt Sensitivity in Response to Renal Injury Requires Renal Angiotensin-Converting Enzyme.Hypertension (Dallas, Tex. : 1979) · 2015Article
- Gut microbiota in hypertension.Current opinion in nephrology and hypertension · 2015Review
- Roles of collecting duct renin and (pro)renin receptor in hypertension: mini review.Therapeutic advances in cardiovascular disease · 2015Review
- The intrarenal generation of angiotensin II is required for experimental hypertension.Current opinion in pharmacology · 2015Review
- Salt feedback on the renin-angiotensin-aldosterone system.Pflugers Archiv : European journal of physiology · 2015Review
- Salt-Sensitive Hypertension: Perspectives on Intrarenal Mechanisms.Current hypertension reviews · 2015Review
- Renin and the (pro)renin receptor in the renal collecting duct: Role in the pathogenesis of hypertension.Clinical and experimental pharmacology & physiology · 2015Review
- Angiotensin II increases the expression of (pro)renin receptor during low-salt conditions.The American journal of the medical sciences · 2014Article
- Renoprotective effects of direct renin inhibition in glomerulonephritis.The American journal of the medical sciences · 2014Article
- Renal generation of angiotensin II and the pathogenesis of hypertension.Current hypertension reports · 2014Review
- Angiotensin II and vascular injury.Current hypertension reports · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Sustained stimulation of the intrarenal/intratubular renin-angiotensin system in a setting of elevated arterial pressure elicits renal vasoconstriction, increased sodium reabsorption, proliferation, fibrosis, and eventual renal injury. Activation of luminal AT(1) receptors in proximal and distal nephron segments by local Ang II formation stimulates various transport systems. Augmented angiotensinogen (AGT) production by proximal tubule cells increases AGT secretion contributing to increased proximal Ang II levels and leading to spillover of AGT into the distal nephron segments, as reflected by increased urinary AGT excretion. The increased distal delivery of AGT provides substrate for renin, which is expressed in principal cells of the collecting tubule and collecting ducts, and is also stimulated by AT(1) receptor activation. Renin and prorenin are secreted into the tubular lumen and act on the AGT delivered from the proximal tubule to form more Ang I. The catalytic actions of renin and or prorenin may be enhanced by binding to prorenin receptors on the intercalated cells or soluble prorenin receptor secreted into the tubular fluid. There is also increased luminal angiotensin converting enzyme in collecting ducts facilitating Ang II formation leading to stimulation of sodium reabsorption via sodium channel and sodium/chloride co-transporter. Thus, increased collecting duct renin contributes to Ang II-dependent hypertension by augmenting distal nephron intratubular Ang II formation leading to sustained stimulation of sodium reabsorption and progression of hypertension.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.