Evidence map›Paper›PMID 22990598›Full record

ArticleJournal of computational neuroscience2013

Inferring evoked brain connectivity through adaptive perturbation.

Kyle Q Lepage, ShiNung Ching, Mark A Kramer

Abstract read
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In one paragraph

Article in Journal of computational neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Kyle Q LepageDepartment of Mathematics & Statistics, Boston University, Boston, MA 02215, USA. lepage@math.bu.edu
ShiNung Ching
Mark A Kramer
Boston University · USMassachusetts General Hospital · US

Funding

A Systems Neuroscience Approach for the Study of General AnesthesiaDP1OD003646 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI BROWN, EMERY N · 2007 to 2011
$4.4M
NIH HHS DP1OD003646
6 · The paper itself

Abstract

Inference of functional networks-representing the statistical associations between time series recorded from multiple sensors-has found important applications in neuroscience. However, networksexhibiting time-locked activity between physically independent elements can bias functional connectivity estimates employing passive measurements. Here, a perturbative and adaptive method of inferring network connectivity based on measurement and stimulation-so called "evoked network connectivity" is introduced. This procedure, employing a recursive Bayesian update scheme, allows principled network stimulation given a current network estimate inferred from all previous stimulations and recordings. The method decouples stimulus and detector design from network inference and can be suitably applied to a wide range of clinical and basic neuroscience related problems. The proposed method demonstrates improved accuracy compared to network inference based on passive observation of node dynamics and an increased rate of convergence relative to network estimation employing a naïve stimulation strategy.

Indexed as

Computer SimulationModels, NeurologicalAnimalsBayes TheoremBiological ClocksBiophysicsBrainHumansNeural Networks, Computer

Identifiers

PMID22990598
OpenAlexW2014484520

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.