ArticleNucleus (Austin, Tex.)
Nucleosome spacing and chromatin higher-order folding.
Article in Nucleus (Austin, Tex.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Conformations of Linker Histone H1 Bound to Nucleosome Arrays.Journal of molecular biology · 2026Article
- Histone Modifications in the Cell Cycle ofEpigenomes · 2026Review
- Nucleosome spacing across cell types, diseases, and ages.Nucleic acids research · 2026Review
- Nucleosome spacing can fine-tune higher-order chromatin assembly.Nature communications · 2025Article
- Introducing the PARCH Scale for Quantifying the Hydropathy of Nucleic Acids and Nucleic Acid-Protein Complexes.Langmuir : the ACS journal of surfaces and colloids · 2025Article
- Genome wide nucleosome landscape shapes 3D chromatin organization.Science advances · 2024Article
- Cryoelectron tomography reveals the multiplex anatomy of condensed native chromatin and its unfolding by histone citrullination.Molecular cell · 2023Article
- Electronic Mapping of a Bacterial Genome with Dual Solid-State Nanopores and Active Single-Molecule Control.ACS nano · 2022Article
- Slow nucleosome dynamics set the transcriptional speed limit and induce RNA polymerase II traffic jams and bursts.PLoS computational biology · 2022Article
- Histone Tail Conformations: A Fuzzy Affair with DNA.Trends in biochemical sciences · 2021Review
- On the role of transcription in positioning nucleosomes.PLoS computational biology · 2021Article
- Elucidating the influence of linker histone variants on chromatosome dynamics and energetics.Nucleic acids research · 2020Article
- Rouse model with transient intramolecular contacts on a timescale of seconds recapitulates folding and fluctuation of yeast chromosomes.Nucleic acids research · 2019Article
- Chromatin fiber structural motifs as regulatory hubs of genome function?Essays in biochemistry · 2019Review
- Chromatin remodeler CHD1 promotes XPC-to-TFIIH handover of nucleosomal UV lesions in nucleotide excision repair.The EMBO journal · 2017Article
- Single-molecule force spectroscopy on histone H4 tail-cross-linked chromatin reveals fiber folding.The Journal of biological chemistry · 2017Article
- DNA Methylation Landscape Reflects the Spatial Organization of Chromatin in Different Cells.Biophysical journal · 2017Article
- Epigenetic characteristics of the mitotic chromosome in 1D and 3D.Critical reviews in biochemistry and molecular biology · 2017Review
- Regulation of nucleosome positioning by a CHD Type III chromatin remodeler and its relationship to developmental gene expression inGenome research · 2017Article
- Correlation among DNA Linker Length, Linker Histone Concentration, and Histone Tails in Chromatin.Biophysical journal · 2016Article
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1 author.
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Abstract
Packing of about two meters of the human genome DNA into chromatin occupying a several micron-sized cell nucleus requires a high degree of compaction in a manner that allows the information encoded on DNA to remain easily accessible. This packing is mediated by repeated coiling of DNA double helix around histones to form nucleosome arrays that are further folded into higher-order structures. Relatively straight DNA linkers separate the nucleosomes and the spacing between consecutive nucleosome varies between different cells and between different chromosomal loci. In a recent work ( 1) our group used a biochemically defined in vitro reconstituted system to explore how do various DNA linkers mediate nucleosome array packing into higher-order chromatin structures. For long nucleosome linkers (about 60 bp) we observed a more open chromatin structure and no effect of small linker length alterations (±2-4 bp) on chromatin folding. In striking contrast, for shorter linkers (20-32 bp) we found more compact packing with strong periodical dependence upon the linker DNA lengths. Our data together with high-resolution nucleosome position mapping provide evidence for the natural nucleosome repeats to support a chromatin architecture that, by default, restricts spontaneous folding of nucleosome arrays into compact chromatin fibers. We suggest that incomplete folding of the nucleosome arrays may promote global inter-array interactions that lead to chromatin condensation in metaphase chromosomes and heterochromatin.
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