ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2012
In vivo detection of brain Krebs cycle intermediate by hyperpolarized magnetic resonance.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
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Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it.
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- Feasibility of multimodal metabolic analysis for detecting early changes in acute neuroinflammation.Journal of neuroinflammation · 2026Article
- Challenges of Investigating Compartmentalized Brain Energy Metabolism Using Nuclear Magnetic Resonance Spectroscopy in vivo.Neurochemical research · 2025Review
- Rapid in situ carbon-13 hyperpolarization and imaging of acetate and pyruvate esters without external polarizer.Communications chemistry · 2024Article
- MATRESHCA: Microtesla Apparatus for Transfer of Resonance Enhancement of Spin Hyperpolarization via Chemical Exchange and Addition.Analytical chemistry · 2024Article
- Parahydrogen-Induced Carbon-13 Radiofrequency Amplification by Stimulated Emission of Radiation.Angewandte Chemie (International ed. in English) · 2023Article
- Schizophrenia: a disorder of broken brain bioenergetics.Molecular psychiatry · 2022Review
- Background-Free Proton NMR Spectroscopy with Radiofrequency Amplification by Stimulated Emission Radiation.Angewandte Chemie (International ed. in English) · 2021Article
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- Denoising of hyperpolarizedMagnetic resonance in medicine · 2021Article
- PHIP hyperpolarized [1-Scientific reports · 2021Article
- Other types of diffuse liver disease: is there a way to do it?Abdominal radiology (New York) · 2020Review
- Imaging Brain Metabolism Using HyperpolarizedTrends in neurosciences · 2020Review
- A Review of Non-IEEE open journal of engineering in medicine and biology · 2020Article
- Increased flow rate of hyperpolarized aqueous solution for dynamic nuclear polarization-enhanced magnetic resonance imaging achieved by an open Fabry-Pérot type microwave resonator.Magnetic resonance (Gottingen, Germany) · 2020Article
- Brain metabolism under different anesthetic conditions using hyperpolarized [1-NMR in biomedicine · 2018Article
- Metabolic and Molecular Imaging with Hyperpolarised Tracers.Molecular imaging and biology · 2018Review
- Effects of Deuteration ofThe journal of physical chemistry. C, Nanomaterials and interfaces · 2018Article
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- Toward Cleavable Metabolic/pH Sensing "Double Agents" Hyperpolarized by NMR Signal Amplification by Reversible Exchange.Chemistry (Weinheim an der Bergstrasse, Germany) · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Krebs (or tricarboxylic acid (TCA)) cycle has a central role in the regulation of brain energy regulation and metabolism, yet brain TCA cycle intermediates have never been directly detected in vivo. This study reports the first direct in vivo observation of a TCA cycle intermediate in intact brain, namely, 2-oxoglutarate, a key biomolecule connecting metabolism to neuronal activity. Our observation reveals important information about in vivo biochemical processes hitherto considered undetectable. In particular, it provides direct evidence that transport across the inner mitochondria membrane is rate limiting in the brain. The hyperpolarized magnetic resonance protocol designed for this study opens the way to direct and real-time studies of TCA cycle kinetics.
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