ArticleAmerican journal of Alzheimer's disease and other dementias2012
Neuropsychological and neuroimaging markers in early versus late-onset Alzheimer's disease.
Article in American journal of Alzheimer's disease and other dementias, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Tau topography subtypes account for clinical heterogeneity and longitudinal trajectories in early-onset Alzheimer's disease.Brain communications · 2026Article
- Efficacy of lecanemab in early-onset Alzheimer's disease with a novel PSEN1 (p.Met233Thr) mutation: a case report.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Facets of language performance in early-onset and late-onset Alzheimer's disease dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Facets of language performance in early-onset and late-onset Alzheimer's disease dementia.medRxiv : the preprint server for health sciences · 2025Article
- Clinical characteristics and biomarker profile in early- and late-onset Alzheimer's disease: the Shanghai Memory Study.Brain communications · 2025Article
- Molecular neuroimaging in dominantly inherited versus sporadic early-onset Alzheimer's disease.Brain communications · 2024Article
- The APOE4 effect: structural brain differences in Alzheimer's disease according to the age at symptom onset.European journal of neurology · 2023Article
- Longitudinal clinical, cognitive and biomarker profiles in dominantly inherited versus sporadic early-onset Alzheimer's disease.Brain communications · 2023Article
- Clinical Manifestations of Early-Onset Dementia With Lewy Bodies Compared With Late-Onset Dementia With Lewy Bodies and Early-Onset Alzheimer Disease.JAMA neurology · 2022Article
- Plasma metabolomics of presymptomatic PSEN1-H163Y mutation carriers: a pilot study.Annals of clinical and translational neurology · 2021Article
- Effects of Alzheimer's and Vascular Pathologies on Structural Connectivity in Early- and Late-Onset Alzheimer's Disease.Frontiers in neuroscience · 2021Article
- The combined effects of microglia activation and brain glucose hypometabolism in early-onset Alzheimer's disease.Alzheimer's research & therapy · 2020Article
- Progressive dysexecutive syndrome due to Alzheimer's disease: a description of 55 cases and comparison to other phenotypes.Brain communications · 2020Article
- Early-onset Alzheimer Disease and Its Variants.Continuum (Minneapolis, Minn.) · 2019Review
- Changes in cerebral metabolic activity in men undergoing androgen deprivation therapy for non-metastatic prostate cancer.Prostate cancer and prostatic diseases · 2018Article
- Neuropsychiatric Profile in Early Versus Late Onset Alzheimer's Disease.American journal of Alzheimer's disease and other dementias · 2018Article
- Functional Connectivity of the Hippocampus in Early- and vs. Late-Onset Alzheimer's Disease.Journal of clinical neurology (Seoul, Korea) · 2017Article
- Relationships between cognitive impairment on ADAS-cog and regional cerebral blood flow using SPECT in late-onset Alzheimer's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2017Article
- Early-Onset Alzheimer Disease.Neurologic clinics · 2017Review
- Effect of age at onset on cortical thickness and cognition in posterior cortical atrophy.Neurobiology of aging · 2016Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundEarly-onset Alzheimer's disease (EOAD) has been overshadowed by the more common late-onset AD (LOAD). Yet, the literature indicates EOAD may have less hippocampal-memory presentations and more focal neocortical localization early in the disease.
objectiveTo evaluate these proposed differences between these 2 forms of AD and to explore what they inform about differences in AD pathophysiology.
methodsIn all, 21 patients with EOAD and 24 patients with LOAD matched for disease progression and severity were compared on neurocognitive measures and resting state fluorodeoxy-glucose positron-emission tomography (FDG-PET).
resultsPatients with EOAD had worse executive functions with greater hypometabolism in the parietal regions; whereas patients with LOAD had worse confrontation naming and verbal recognition memory with greater hypometabolism in inferior frontotemporal regions.
conclusionsIn addition to highlighting significant differences between EOAD and LOAD, these results reveal dissociation between executive deficits in AD and frontal hypometabolism, suggesting early disturbances of the parietal-frontal network in EOAD.
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