ArticleThe international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease2012
Impact of rapid drug susceptibility testing for tuberculosis: program experience in Lima, Peru.
Article in The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 17 citations in OpenAlex.
- Implementation of whole genome sequencing for tuberculosis diagnostics in a low-middle income, high MDR-TB burden country.Scientific reports · 2021Article
- Time to Multidrug-Resistant Tuberculosis Treatment Initiation in Association with Treatment Outcomes in Shanghai, China.Antimicrobial agents and chemotherapy · 2018Article
- Outcomes from patients with presumed drug resistant tuberculosis in five reference centers in Brazil.BMC infectious diseases · 2017Observational
- Impact of HIV on mortality among patients treated for tuberculosis in Lima, Peru: a prospective cohort study.BMC infectious diseases · 2016Article
- Clinical characteristics, drug resistance, and treatment outcomes among tuberculosis patients with diabetes in Peru.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2013Article
- Alignment of new tuberculosis drug regimens and drug susceptibility testing: a framework for action.The Lancet. Infectious diseases · 2013Review
Corrections and comments
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Authors and funding
13 authors at 7 institutions in 2 countries.
Funding
Abstract
settingProgrammatic implementation of decentralized rapid drug susceptibility testing (DST) in Lima, Peru.
objectivePre-post analysis compared time to diagnosis, treatment outcome and survival among patients tested with direct nitrate reductase assay (NRA) vs. indirect conventional methods.
designFrom 2005 to 2009, we prospectively followed all patients referred for DST before (control) and after (intervention) NRA implementation. Among those referred for DST, NRA was used for smear-positive samples of patients with no prior history of multidrug resistance or treatment for multidrug-resistant tuberculosis (TB). Data were abstracted from patient charts and laboratory registers. Endpoints were favorable outcomes, time to result and time to death.
resultsOf those patients who met the criteria for NRA, 740 underwent NRA and 621 underwent conventional DST. NRA yielded test results for 78.4% of cases vs. 68.8% for conventional DST (P < 0.0001); the median time to result was 44 vs. 133 days, respectively (adjusted HR 0.64, 95%CI 0.56-0.73). Among individuals without previous anti-tuberculosis treatment, NRA was associated with a favorable treatment outcome (adjusted OR 1.39, 95%CI 1.01-1.90) and prolonged survival (adjusted HR 0.53, 95%CI 0.31-0.90).
conclusionDirect NRA significantly shortened time to test result and improved treatment outcomes and survival in certain groups.
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