Trial reportThe American journal of clinical nutrition2012
The effect of prepubertal calcium carbonate supplementation on the age of peak height velocity in Gambian adolescents.
Trial report in The American journal of clinical nutrition, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Hard facts and misfits: essential ingredients of public health nutrition research.The Proceedings of the Nutrition Society · 2021Pooled it
- Evidence of an overweight/obesity transition among school-aged children and youth in Sub-Saharan Africa: a systematic review.PloS one · 2014Pooled it
- Trial
- Trial
- The effect of prepubertal calcium carbonate supplementation on skeletal development in Gambian boys-a 12-year follow-up study.The Journal of clinical endocrinology and metabolism · 2014Trial
- Unexpected long-term effects of calcium supplementation in pregnancy on maternal bone outcomes in women with a low calcium intake: a follow-up study.The American journal of clinical nutrition · 2013Trial
- Contribution of direct-drinking water to calcium and magnesium and the influence on the height in school-age children.Frontiers in nutrition · 2024Article
- The estimation of pubertal growth spurt parameters using the superimposition by translation and rotation model in Korean children and adolescents: a longitudinal cohort study.Frontiers in pediatrics · 2024Article
- Nutritional status of school-age children and adolescents in low- and middle-income countries across seven global regions: a synthesis of scoping reviews.Public health nutrition · 2023Review
- Longitudinal Height Growth in Children and Adolescents with Type-1 Diabetes Mellitus Compared to Controls in Pune, India.Pediatric diabetes · 2023Article
- Review Nutritional interventions during adolescence and their possible effects.Acta bio-medica : Atenei Parmensis · 2022Review
- Anthropometric nutritional status, and social and dietary characteristics of African and Indian adolescents taking part in the TALENT (Transforming Adolescent Lives through Nutrition) qualitative study.Public health nutrition · 2021Article
- Exploring influences on adolescent diet and physical activity in rural Gambia, West Africa: food insecurity, culture and the natural environment.Public health nutrition · 2021Article
- Prevalence and Predictors of Hypocalcaemia among Adolescent Girls in Rural Public Secondary Schools in South-South Nigeria.Ethiopian journal of health sciences · 2021Article
- How do we improve adolescent diet and physical activity in India and sub-Saharan Africa? Findings from the Transforming Adolescent Lives through Nutrition (TALENT) consortium.Public health nutrition · 2021Article
- Sex differences in requirements for micronutrients across the lifecourse.The Proceedings of the Nutrition Society · 2021Article
- Article
- Effects of preventive nutrition interventions among adolescents on health and nutritional status in low- and middle-income countries: A systematic review.Campbell systematic reviews · 2020Review
- Optimal design for longitudinal studies to estimate pubertal height growth in individuals.Annals of human biology · 2018Article
- Using SITAR (SuperImposition by Translation and Rotation) to estimate age at peak height velocity in Avon Longitudinal Study of Parents and Children.Wellcome open research · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundLimited evidence suggests that calcium intake before puberty influences adolescent height growth and the timing of puberty. Such an effect might be particularly marked in populations in whom low calcium intake, stunting, and delayed puberty are common.
objectiveThe objective was to test whether 12 mo of calcium supplementation at age 8-12 y to increase intakes toward international recommendations had long-term effects on adolescent growth and pubertal development in rural Gambian children.
designThis was a longitudinal study of 160 Gambian boys (n = 80) and girls (n = 80) who had participated in a 12-mo, randomized, double-blind, placebo-controlled, calcium carbonate supplementation trial (1000 mg Ca/d, 5 d/wk) at age 8-12 y. Anthropometric measures were made every 1-2 y until age 21-25 y; pubertal status and menarche data were collected. Repeated-measures ANCOVA and Superimposition by Translation and Rotation Method (SITAR) growth models were used to assess the effects of treatment.
resultsIn boys, midadolescent height growth was advanced in the calcium group, which resulted in greater stature at a mean age of 15.5 y (mean ± SEM: 2.0 ± 0.8 cm; P = 0.01) and an earlier age of peak height velocity by 7.4 ± 2.9 mo. Subsequently, the calcium group stopped growing earlier (P = 0.02) and was 3.5 ± 1.1 cm shorter (P = 0.002) at a mean age of 23.5 y. Weight and midupper arm circumference paralleled height. No significant effects were observed in girls, but a sex-by-supplement interaction on height growth could not be confirmed.
conclusionCalcium supplementation of boys in late childhood advanced the age of peak height velocity and resulted in shorter adult stature in a population in whom low calcium intakes and delayed puberty are common. This trial was registered at isrctn.org as ISRCTN28836000.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.