ReviewJournal of the Chinese Medical Association : JCMA2012
Primary hyperparathyroidism in children and adolescents.
Review in Journal of the Chinese Medical Association : JCMA, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it, 116 citations in OpenAlex.
- A meta-analysis comparing the biochemistry of primary hyperparathyroidism in youths to the biochemistry of primary hyperparathyroidism in adults.The Journal of clinical endocrinology and metabolism · 2014Pooled it
- Primary Hyperparathyroidism in the Pediatric Population: Surgical Considerations and Outcomes: A Narrative Review.Diagnostics (Basel, Switzerland) · 2026Review
- Three Malagasy Cases of Severe Bone Complications Revealing Primary Hyperparathyroidism.Case reports in endocrinology · 2026Article
- A Primary Hyperparathyroidism in an Adolescent Female with Pathological Fractures and Multiple Bone Lesions Due to Parathyroid Adenoma: Case Report.Journal of orthopaedic case reports · 2025Article
- Recurrent acute pancreatitis and primary hyperparathyroidism in patients presenting to the emergency department: Diagnostic challenges.World journal of clinical cases · 2025Article
- Bilateral renal stones secondary to primary hyperparathyroidism in a 13-year-old boy: a case report.Childhood kidney diseases · 2025Article
- Transcriptome sequencing reveals distinct atypical parathyroid tumor subtypes.Endocrine-related cancer · 2025Article
- Neonatal Severe Hyperparathyroidism: Anaesthetic Considerations for Removal of Pea-size Glands in Children.Turkish journal of anaesthesiology and reanimation · 2025Article
- Primary hyperparathyroidism in children: Insights from a single-center cohort.Pediatric endocrinology, diabetes, and metabolism · 2025Article
- Atypical parathyroid adenoma with severe bone manifestations in early adolescence.BMJ case reports · 2024Article
- A case report of primary hyperparathyroidism in an adolescent during Ramadan fast.SAGE open medical case reports · 2024Article
- Combination approach forTherapeutic advances in medical oncology · 2024Article
- Pediatric Neuroendocrine Neoplasia of the Parathyroid Glands: Delving into Primary Hyperparathyroidism.Biomedicines · 2023Review
- [Primary hyperparathyroidism in children].Problemy endokrinologii · 2023Observational
- Primary hyperparathyroidism in an adolescent presenting with genu valgus progressing to extensive bone disease; a case report.BMC endocrine disorders · 2023Article
- Femoral Neck Fracture in a Pediatric Patient with Primary Hyperparathyroidism.Case reports in orthopedics · 2023Article
- A Giant Parathyroid Adenoma Presenting as Nausea, Vomiting, and Headaches in an Adolescent Male.Case reports in pediatrics · 2023Article
- Clinical Profile of Parathyroid Adenoma in Children and Adolescents: A Single-Center Experience.Turkish archives of pediatrics · 2023Article
- Bone Fracture in an Adolescent: Just Tip of the Iceberg in Metabolic Bone Disease.Turkish archives of pediatrics · 2022Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Primary hyperparathyroidism (PHPT) is a common endocrine disorder in adults in whom the typical presentation is incidentally discovered as asymptomatic hypercalcemia. PHPT is much less common in children and adolescents, but has greater morbidity in this age group, as most young patients with PHPT will have symptomatic hypercalcemia or complications such as kidney stones, abdominal pain, and skeletal fragility. An important feature of PHPT in younger patients is the relatively high prevalence of germline inactivating mutations of the CASR gene, which encodes the calcium-sensing receptor. Biallelic CASR mutations cause neonatal severe hyperparathyroidism, a life-threatening condition that presents within days of life with marked hypercalcemia, respiratory distress, failure to thrive, and skeletal demineralization. By contrast, more common heterozygous CASR mutations are generally associated with a benign variant of PHPT termed familial hypocalciuric hypercalcemia. Appropriate management of PHPT in children and adolescents requires distinction between familial hypocalciuric hypercalcemia, which generally requires no specific treatment, and other forms of PHPT that are best treated by parathyroidectomy.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.