ArticleFluids and barriers of the CNS2012
Diffusion tensor imaging in elderly patients with idiopathic normal pressure hydrocephalus or Parkinson's disease: diagnosis of gait abnormalities.
Article in Fluids and barriers of the CNS, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 43 citations in OpenAlex.
- White matter lesions associated with the reemergence of grasp reflexes in patients with idiopathic normal pressure hydrocephalus.Fluids and barriers of the CNS · 2025Article
- Hydrocephalus: Molecular and Neuroimaging Biomarkers in Diagnosis and Management.Biomedicines · 2025Review
- Alterations of diffusion kurtosis measures in gait-related white matter in the "ON-OFF state" of Parkinson's disease.Chinese medical journal · 2025Article
- Radiological features of gait phenotypes in patients with idiopathic normal pressure hydrocephalus.Frontiers in aging neuroscience · 2025Article
- Structural and functional connectivity in hydrocephalus: a scoping review.Neurosurgical review · 2024Article
- Structural neuroimaging markers of normal pressure hydrocephalus versus Alzheimer's dementia and Parkinson's disease, and hydrocephalus versus atrophy in chronic TBI-a narrative review.Frontiers in neurology · 2024Review
- Relationship between disproportionately enlarged subarachnoid-space hydrocephalus and white matter tract integrity in normal pressure hydrocephalus.Scientific reports · 2023Article
- Sphingolipid abnormalities in encephalomyeloradiculoneuropathy (EMRN) are associated with an anti-neutral glycolipid antibody.FEBS open bio · 2023Review
- X-linked hydrocephalus genes: Their proximity to telomeres and high A + T content compared to Parkinson's disease.Experimental neurology · 2023Review
- Imaging Markers for Normal Pressure Hydrocephalus: An Overview.Biomedicines · 2023Review
- Assessing white matter microstructural changes in idiopathic normal pressure hydrocephalus using voxel-based R2* relaxometry analysis.Frontiers in neurology · 2023Article
- The role of diffusion tensor imaging in idiopathic normal pressure hydrocephalus: A literature review.The neuroradiology journal · 2021Review
- Diffusion tensor imaging in idiopathic normal pressure hydrocephalus: clinical and CSF flowmetry correlations.The neuroradiology journal · 2020Article
- Brain imaging of locomotion in neurological conditions.Neurophysiologie clinique = Clinical neurophysiology · 2018Review
- Different neural substrates for precision stepping and fast online step adjustments in youth.Brain structure & function · 2018Article
- Neuroimaging in Dementia.Seminars in neurology · 2017Review
- Cerebral White Matter and Slow Gait: Contribution of Hyperintensities and Normal-appearing Parenchyma.The journals of gerontology. Series A, Biological sciences and medical sciences · 2016Article
- Article
- Diagnosis and prognosis in idiopathic normal pressure hydrocephalus.American journal of Alzheimer's disease and other dementias · 2014Review
- Differential vulnerability of white matter structures to experimental infantile hydrocephalus detected by diffusion tensor imaging.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2014Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelled
backgroundGait abnormalities in the elderly, characterized by short steps and frozen gait, can be caused by several diseases, including idiopathic normal pressure hydrocephalus (INPH), and Parkinson's disease (PD). We analyzed the relationship between these two conditions and their association with gait abnormalities using laboratory test data and findings from diffusion tensor imaging (DTI).
methodsThe study involved 10 patients with INPH, 18 with PD, and 10 healthy individuals (control group). Fractional anisotropy (FA) of five brain areas was measured and compared among the three groups. In addition, the association of INPH and PD with gait capability, frontal lobe function, and FA of each brain area was evaluated.
resultsThe INPH group had significantly lower FA for anterior thalamic radiation (ATR) and forceps minor (Fmin) as compared to the PD group. The gait capability correlated with ATR FA in the INPH and PD groups. We found that adding DTI to the diagnosis assisted the differential diagnosis of INPH from PD, beyond what could be inferred from ventricular size alone.
conclusionsWe expect that DTI will provide a useful tool to support the differential diagnosis of INPH and PD and their respective severities.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.