ArticleThe Journal of clinical investigation1990
Atherogenic diet increases cholesteryl ester transfer protein messenger RNA levels in rabbit liver.
Article in The Journal of clinical investigation, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 136 citations in OpenAlex.
- Serum CETP status is independently associated with reduction rates in LDL-C in pitavastatin-treated diabetic patients and possible involvement of LXR in its association.Lipids in health and disease · 2016Trial
- Trial
- A dose-response study of the effects of dietary cholesterol on fasting and postprandial lipid and lipoprotein metabolism in healthy young men.Arteriosclerosis and thrombosis : a journal of vascular biology · 1994Trial
- Cinnamaldehyde exerts vasculoprotective effects in hypercholestrolemic rabbits.Naunyn-Schmiedeberg's archives of pharmacology · 2018Article
- Cholesteryl ester transfer protein and its inhibitors.Journal of lipid research · 2018Review
- High level of serum cholesteryl ester transfer protein in active hepatitis C virus infection.World journal of hepatology · 2016Article
- Plasma lipid profiling across species for the identification of optimal animal models of human dyslipidemia.Journal of lipid research · 2012Article
- Pharmacological inhibition of ABCA1 degradation increases HDL biogenesis and exhibits antiatherogenesis.Journal of lipid research · 2009Article
- Molecular cloning of hamster lipid transfer inhibitor protein (apolipoprotein F) and regulation of its expression by hyperlipidemia.Journal of lipid research · 2009Article
- Effects of cholesterol ester transfer protein (CETP) gene on adiposity in response to long-term overfeeding.Atherosclerosis · 2008Article
- The levels of plasma low density lipoprotein are independent of cholesterol ester transfer protein in fish-oil fed F1B hamsters.Nutrition & metabolism · 2005Article
- Apolipoprotein CI overexpression is not a relevant strategy to block cholesteryl ester transfer protein (CETP) activity in CETP transgenic mice.The Biochemical journal · 2005Article
- Regulation by long-chain fatty acids of the expression of cholesteryl ester transfer protein in HepG2 cells.Lipids · 2001Article
- Sterol upregulation of human CETP expression in vitro and in transgenic mice by an LXR element.The Journal of clinical investigation · 2000Article
- Overexpression of lecithin:cholesterol acyltransferase in transgenic rabbits prevents diet-induced atherosclerosis.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Profound induction of hepatic cholesteryl ester transfer protein transgene expression in apolipoprotein E and low density lipoprotein receptor gene knockout mice. A novel mechanism signals changes in plasma cholesterol levels.The Journal of clinical investigation · 1996Article
- Decreased cholesteryl ester transfer protein (CETP) mRNA and protein and increased high density lipoprotein following lipopolysaccharide administration in human CETP transgenic mice.The Journal of clinical investigation · 1995Article
- Dietary cholesterol increases transcription of the human cholesteryl ester transfer protein gene in transgenic mice. Dependence on natural flanking sequences.The Journal of clinical investigation · 1992Article
- Plasma lipid transfer protein as a determinant of the atherogenicity of monkey plasma lipoproteins.The Journal of clinical investigation · 1991Article
- Plasma high density lipoproteins. Metabolism and relationship to atherogenesis.The Journal of clinical investigation · 1990Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Cholesteryl ester transfer activity is increased in plasma of cholesterol-fed rabbits. To investigate the mechanisms leading to changes in activity, we measured cholesteryl ester transfer protein (CETP) mass by RIA and CETP mRNA abundance by Northern and slot blot analysis using a human CETP cDNA probe in control (n = 8) and cholesterol-fed rabbits (n = 10). Cholesterol feeding (chow plus 0.5% cholesterol, 10% corn oil) for 30 d increased CETP mass in plasma 3.2-fold in the cholesterol-fed rabbits (12.45 +/- 0.82 micrograms/ml) compared with controls (3.86 +/- 0.38 micrograms/ml). In the hypercholesterolemic rabbit, liver CETP mRNA levels were increased 2.8 times control mRNA levels. Actin, apo E, lecithin-cholesterol acyltransferase, and albumin mRNA abundances were unchanged. In contrast to the widespread tissue distribution in humans, CETP mRNA was not detected in extrahepatic tissues of either control or cholesterol-fed animals. Using a sensitive RNase protection assay, the increase in liver CETP mRNA was detectable within 3 d of beginning the high cholesterol diet. Thus, in response to the atherogenic diet there is an early increase in liver CETP mRNA, probably causing increased CETP synthesis and secretion, and increased plasma CETP. The results indicate that the CETP gene may be regulated by diet-induced changes in lipid metabolism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.