ArticleBMC psychiatry2012
Sex-related differences in sleep slow wave activity in major depressive disorder: a high-density EEG investigation.
Article in BMC psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- A Systematic Review and Meta-Analysis of Biological Sex Differences in Sleep Spindles and Slow Wave Activity in Adults With and Without Insomnia.Journal of sleep research · 2026Pooled it
- The Effects of Sleep Continuity Disruption on Positive Mood and Sleep Architecture in Healthy Adults.Sleep · 2015Trial
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- Sleep Delta power, age, and sex effects in treatment-resistant depression.Journal of psychiatric research · 2024Article
- Neurobiological Underpinnings of Hyperarousal in Depression: A Comprehensive Review.Brain sciences · 2024Review
- Sex Differences in Stress Response: Classical Mechanisms and Beyond.Current neuropharmacology · 2024Article
- Sex differences in anxiety and depression: circuits and mechanisms.Nature reviews. Neuroscience · 2021Review
- Article
- The Effects of Daytime Psilocybin Administration on Sleep: Implications for Antidepressant Action.Frontiers in pharmacology · 2020Article
- Article
- REM sleep's unique associations with corticosterone regulation, apoptotic pathways, and behavior in chronic stress in mice.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Sex differences in stress reactivity in arousal and attention systems.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Review
- Sex differences in stress regulation of arousal and cognition.Physiology & behavior · 2018Review
- You'll feel better in the morning: slow wave activity and overnight mood regulation in interepisode bipolar disorder.Psychological medicine · 2018Article
- Article
- Effects of oral temazepam on slow waves during non-rapid eye movement sleep in healthy young adults: A high-density EEG investigation.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2016Article
- Effects of partial sleep deprivation on slow waves during non-rapid eye movement sleep: A high density EEG investigation.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2016Article
- The 5α-reductase inhibitor finasteride is not associated with alterations in sleep spindles in men referred for polysomnography.Human psychopharmacology · 2016Article
- Evidence for the role of corticotropin-releasing factor in major depressive disorder.Neuroscience and biobehavioral reviews · 2015Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
backgroundSleep disturbance plays an important role in major depressive disorder (MDD). Prior investigations have demonstrated that slow wave activity (SWA) during sleep is altered in MDD; however, results have not been consistent across studies, which may be due in part to sex-related differences in SWA and/or limited spatial resolution of spectral analyses. This study sought to characterize SWA in MDD utilizing high-density electroencephalography (hdEEG) to examine the topography of SWA across the cortex in MDD, as well as sex-related variation in SWA topography in the disorder.
methodsAll-night recordings with 256 channel hdEEG were collected in 30 unipolar MDD subjects (19 women) and 30 age and sex-matched control subjects. Spectral analyses of SWA were performed to determine group differences. SWA was compared between MDD and controls, including analyses stratified by sex, using statistical non-parametric mapping to correct for multiple comparisons of topographic data.
resultsAs a group, MDD subjects demonstrated significant increases in all-night SWA primarily in bilateral prefrontal channels. When stratified by sex, MDD women demonstrated global increases in SWA relative to age-matched controls that were most consistent in bilateral prefrontal regions; however, MDD men showed no significant differences relative to age-matched controls. Further analyses demonstrated increased SWA in MDD women was most prominent in the first portion of the night.
conclusionsWomen, but not men with MDD demonstrate significant increases in SWA in multiple cortical areas relative to control subjects. Further research is warranted to investigate the role of SWA in MDD, and to clarify how increased SWA in women with MDD is related to the pathophysiology of the disorder.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.