ArticleNutrition journal2012
Long-term interdisciplinary therapy reduces endotoxin level and insulin resistance in obese adolescents.
Article in Nutrition journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 29 citations in OpenAlex.
- Moderate exercise increases endotoxin concentration in hypoxia but not in normoxia: A controlled clinical trial.Medicine · 2017Trial
- Unhealthy Dieting During the COVID-19 Pandemic: An Opinion Regarding the Harmful Effects on Brain Health.Frontiers in nutrition · 2022Article
- Effects of aging and lifelong aerobic exercise on expression of innate immune components in human skeletal muscle.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Detoxification Enhanced Lifestyle Intervention Targeting Endotoxemia (DELITE) in the Setting of Obesity and Pain: Results of a Pilot Group Intervention.Integrative medicine (Encinitas, Calif.) · 2020Review
- The initiation of metabolic inflammation in childhood obesity.The Journal of clinical investigation · 2017Review
- Toxins, Toxicity, and Endotoxemia: A Historical and Clinical Perspective for Chiropractors.Journal of chiropractic humanities · 2016Review
- Animal models in genomic research: Techniques, applications, and roles for nurses.Applied nursing research : ANR · 2016Article
- Weight Loss Mediated Reduction in Xanthine Oxidase Activity and Uric Acid Clearance in Adolescents with Severe Obesity.Childhood obesity (Print) · 2016Article
- Review
- Effects of eight weeks of resistance training on the risk factors of metabolic syndrome in overweight /obese women - "A Pilot Study".Diabetology & metabolic syndrome · 2013Article
- Lipotoxicity: effects of dietary saturated and transfatty acids.Mediators of inflammation · 2013Article
- A plausible explanation for male dominance in typhoid ileal perforation.Clinical and experimental gastroenterology · 2012Article
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThe purpose of the present study was to assess the dietary fat intake, glucose, insulin, Homeostasis model assessment for insulin resistance HOMA-IR, and endotoxin levels and correlate them with adipokine serum concentrations in obese adolescents who had been admitted to long-term interdisciplinary weight-loss therapy.
designThe present study was a longitudinal clinical intervention of interdisciplinary therapy. Adolescents (n = 18, aged 15-19 y) with a body mass index > 95th percentile were admitted and evaluated at baseline and again after 1 year of interdisciplinary therapy. We collected blood samples, and IL-6, adiponectin, and endotoxin concentrations were measured by ELISA. Food intake was measured using 3-day diet records. In addition, we assessed glucose and insulin levels as well as the homeostasis model assessment for insulin resistance (HOMA-IR).
resultsThe most important finding from the present investigation was that the long-term interdisciplinary lifestyle therapy decreased dietary fat intake and endotoxin levels and improved HOMA-IR. We observed positive correlations between dietary fat intake and endotoxin levels, insulin levels, and the HOMA-IR. In addition, endotoxin levels showed positive correlations with IL-6 levels, insulin levels and the HOMA-IR. Interestingly, we observed a negative correlation between serum adiponectin and both dietary fat intake and endotoxin levels.
conclusionsThe present results indicate an association between dietary fat intake and endotoxin level, which was highly correlated with a decreased pro-inflammatory state and an improvement in HOMA-IR. In addition, this benefits effect may be associated with an increased adiponectin level, which suggests that the interdisciplinary therapy was effective in improving inflammatory pathways.
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