ArticleOxidative medicine and cellular longevity2012
Oxygen concentration-dependent oxidative stress levels in rats.
Article in Oxidative medicine and cellular longevity, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Electronic Medical Record-Based Pager Notification Reduces Excess Oxygen Exposure in Mechanically Ventilated Subjects.Respiratory care · 2021Trial
- Impact of extended ginsenoside Rb1 on early chronic kidney disease: a randomized, placebo-controlled study.Inflammopharmacology · 2017Trial
- Optimized oxygen therapy improves sleep deprivation-induced cardiac dysfunction through gut microbiota.Frontiers in cellular and infection microbiology · 2025Article
- Assessing Biocompatibility of Composite Cements by Peri/Intramuscular and Subcutaneous Implantation in Rats.Biomedicines · 2024Article
- Brief Oxygen Exposure after Traumatic Brain Injury Hastens Recovery and Promotes Adaptive Chronic Endoplasmic Reticulum Stress Responses.International journal of molecular sciences · 2023Article
- Exposure to a mild hyperbaric oxygen environment elevates blood pressure.Journal of physical therapy science · 2022Article
- COVID-19-associated cardiovascular morbidity in older adults: a position paper from the Italian Society of Cardiovascular Researches.GeroScience · 2020Review
- The effect of inspired oxygen concentration on oxidative stress biomarkers in dogs under inhalation anesthesia.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2020Article
- Oxygen Enrichment Ameliorates Cardiorespiratory Alterations Induced by Chronic High-Altitude Hypoxia in Rats.Frontiers in physiology · 2020Article
- Mild hyperbaric oxygen and oxygenation under normobaric conditions: response to Dr. Andel's letter submitted to the editor.The journal of physiological sciences : JPS · 2019Article
- Mild hyperbaric oxygen: mechanisms and effects.The journal of physiological sciences : JPS · 2019Review
- Normobaric oxygen: a novel approach for treating chronic cerebral circulation insufficiency.Clinical interventions in aging · 2019Article
- The Impact of Moderate Chronic Hypoxia and Hyperoxia on the Level of Apoptotic and Autophagic Proteins in Myocardial Tissue.Oxidative medicine and cellular longevity · 2018Article
- Unloading-induced atrophy and decreased oxidative capacity of the soleus muscle in rats are reversed by pre- and postconditioning with mild hyperbaric oxygen.Physiological reports · 2017Article
- Re-evaluation of the WHO (2010) formaldehyde indoor air quality guideline for cancer risk assessment.Archives of toxicology · 2017Review
- The protective effect of lycopene intake on bone loss in ovariectomized rats.Journal of bone and mineral metabolism · 2015Article
- Effect of intermittent hyperoxia on stem cell mobilization and cytokine expression.Medical gas researchArticle
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
introductionWe determined derivatives of reactive oxygen metabolites (dROMs) as an index of oxidative stress level (oxidant capacity) and biochemical antioxidant potential (BAP) as an index of antioxidant capacity in rats exposed to different oxygen concentrations.
methodsMale Wistar rats were exposed to 14.4%, 20.9%, 35.5%, 39.8%, 62.5%, and 82.2% oxygen at 1 atmosphere absolute for 24 h. Serum levels of dROMs and BAP were examined by using a free radical and antioxidant potential determination device. The morphological characteristics of red blood cells were examined by phase contrast microscopy.
resultsThere were no differences in the levels of dROMs in rats exposed to 14.4%, 20.9%, and 35.5% oxygen. However, the levels of dROMs increased in the rats exposed to 39.8% and 62.5% oxygen. The levels of dROMs were the highest in the rats exposed to 82.2% oxygen. There were no differences in the levels of BAP with respect to the oxygen concentration. Morphological changes in the red blood cells induced by oxidative attack from reactive oxygen species were observed in the rats exposed to 39.8%, 62.5%, and 82.2% oxygen.
conclusionOur results suggest that exposure to oxygen concentrations higher than 40% for 24 h induces excessive levels of oxidative stress in rats.
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