ArticleEvidence-based complementary and alternative medicine : eCAM2012
Anti-Inflammatory Effect of Triterpene Saponins Isolated from Blue Cohosh (Caulophyllum thalictroides).
Article in Evidence-based complementary and alternative medicine : eCAM, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Article
- Two previously undescribed triterpenoid saponins from the roots and rhizomes ofFrontiers in chemistry · 2024Article
- Isolation and Characterization of the Genes Involved in the Berberine Synthesis Pathway in Asian Blue Cohosh,Plants (Basel, Switzerland) · 2023Article
- Synergistic Antimicrobial Effects of CefabronchinEuropean journal of microbiology & immunology · 2019Article
- The Phytochemistry of Cherokee Aromatic Medicinal Plants.Medicines (Basel, Switzerland) · 2018Review
- Herbal fertility treatments used in North America from colonial times to 1900, and their potential for improving the success rate of assisted reproductive technology.Reproductive biomedicine & society online · 2018Article
- Studies on phytochemical, antioxidant, anti-inflammatory, hypoglycaemic and antiproliferative activities of Echinacea purpurea and Echinacea angustifolia extracts.Pharmaceutical biology · 2017Article
- Spectrum-Effect Relationships between Fingerprints of Caulophyllum robustum Maxim and Inhabited Pro-Inflammation Cytokine Effects.Molecules (Basel, Switzerland) · 2017Article
- Pharmacological Effect ofEvidence-based complementary and alternative medicine : eCAM · 2017Article
- Systems Pharmacological Approach ofEvidence-based complementary and alternative medicine : eCAM · 2017Article
- Hypoglycemic agents and potential anti-inflammatory activity.Journal of inflammation research · 2016Review
- Protective effect of centella triterpene saponins against cyclophosphamide-induced immune and hepatic system dysfunction in rats: its possible mechanisms of action.Journal of physiology and biochemistry · 2015Article
- Genus caulophyllum: an overview of chemistry and bioactivity.Evidence-based complementary and alternative medicine : eCAM · 2014Review
- Immunobiologic and antiinflammatory properties of a bark extract from Ampelozizyphus amazonicus Ducke.BioMed research international · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Blue cohosh has been used as a medicinal herb in eastern North America. It was commonly used as traditional medicines for the treatment of menopausal symptoms, rheumatic pain, and as anti-inflammatory remedy. Particularly, extract of blue cohosh roots has been used as anti-inflammatory antipyretic in traditional medicines. In the present study, we investigated the effects of blue cohosh components on the suppressive expression of iNOS or proinflammatory cytokines after the activation of microglia with lipopolysaccharide (LPS). The expression of iNOS, TNF-α, IL-1β, and IL-6 was determined by western blotting or gene expression. Blue cohosh treatment suppressed the elevation of LPS-induced iNOS expression in a concentration-dependent manner in microglia cells. Blue cohosh constituents also suppressed the expression of TNF-α, IL-1β, and IL-6. In addition, blue cohosh extract suppressed the expression of COX-2, iNOS, and proinflammatory cytokines in adrenal glands of mice. These results demonstrate that constituents of blue cohosh exert anti-inflammatory effects through the inhibition of expression of iNOS and proinflammatory cytokines. Therefore, blue cohosh may have therapeutic potential for the treatment of inflammation-related diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.