ArticleInterdisciplinary perspectives on infectious diseases2012
Leprosy: an overview of pathophysiology.
Article in Interdisciplinary perspectives on infectious diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
65 citing papers in PubMed, 2 syntheses or guidelines pooled it, 201 citations in OpenAlex.
- An update on leprosy immunopathogenesis: systematic review.Frontiers in immunology · 2024Pooled it
- Inflammatory Mediators of Leprosy Reactional Episodes and Dental Infections: A Systematic Review.Mediators of inflammation · 2015Pooled it
- Structural aspects of lesional and non-lesional skin microbiota reveal key community changes in leprosy patients from India.Scientific reports · 2021Trial
- Safety and efficacy assessment of two new leprosy skin test antigens: randomized double blind clinical study.PLoS neglected tropical diseases · 2014Trial
- Overcoming the last mile: practical strategies for leprosy elimination in Pakistan.BMJ global health · 2026Article
- Exploring generational differences in the impact of stigma on mental health among people affected by leprosy in rural India: a qualitative study.Scientific reports · 2026Article
- Article
- Serum levels of Interleukin-10, Interleukin-6, and leptin in patients with Mycobacterium leprae-Helminth Co-Infections.BMC infectious diseases · 2025Observational
- Alleviation of mycobacterial infection by impairing motility and biofilm formation via natural and synthetic molecules.World journal of microbiology & biotechnology · 2025Review
- Ulnar nerve mononeuropathy in a patient with Hansen's disease: Clinical and radiological features.The neuroradiology journal · 2025Article
- Perforating ENL: A variant of type 2 lepra reaction.Journal of clinical tuberculosis and other mycobacterial diseases · 2025Article
- Immune mediators as plasma biomarkers for identifying household contacts and classifying clinical forms and leprosy reactions.Frontiers in immunology · 2025Article
- Socioeconomic determinants of the leprosy risk in Yunnan Province, China: a county-level spatiotemporal study.Frontiers in public health · 2025Article
- Exploring the Neurological Manifestations of Leprosy: Clinical Insights and Implications.Cureus · 2025Review
- Pure Neuritic Leprosy In Children With Grade 2 Disability On Hands And Feet: A Rare Case And Literature Review.International medical case reports journal · 2025Article
- The Neurological Impact of Leprosy: Manifestations and Treatment Approaches.Neurology international · 2024Review
- Dr. Indira Nath: Innovator in Leprosy Immunology and a Beacon of Scientific Excellence.Cureus · 2024Review
- A comparative study on the detection of Mycobacterium leprae DNA in urine samples of leprosy patients using Rlep-PCR with other conventional samples.Molecular biology reports · 2024Article
- Review
- Unlocking Opportunities forACS infectious diseases · 2024Review
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Leprosy, also known as Hansen's disease, is a chronic infectious disease caused by Mycobacterium leprae, a microorganism that has a predilection for the skin and nerves. The disease is clinically characterized by one or more of the three cardinal signs: hypopigmented or erythematous skin patches with definite loss of sensation, thickened peripheral nerves, and acid-fast bacilli detected on skin smears or biopsy material. M. leprae primarily infects Schwann cells in the peripheral nerves leading to nerve damage and the development of disabilities. Despite reduced prevalence of M. leprae infection in the endemic countries following implementation of multidrug therapy (MDT) program by WHO to treat leprosy, new case detection rates are still high-indicating active transmission. The susceptibility to the mycobacteria and the clinical course of the disease are attributed to the host immune response, which heralds the review of immunopathology of this complex disease.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.