ArticleDermatology research and practice2012
The infant skin barrier: can we preserve, protect, and enhance the barrier?
Article in Dermatology research and practice, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05589038 (A Randomized, Evaluator-Blinded, Clinical Evaluation of a Regimen of a Baby Wash/Shampoo and Baby Lotion Versus Baby Wash/Shampoo Alone for Tolerability and Impact on Skin Barrier and Microbiome on Newborns), which is not on this map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized, Evaluator-Blinded, Clinical Evaluation of a Regimen of a Baby Wash/Shampoo and Baby Lotion Versus Baby Wash/Shampoo Alone for Tolerability and Impact on Skin Barrier and Microbiome on Newborns
Who cites it
33 citing papers in PubMed, 106 citations in OpenAlex.
- Topical emollient therapy in the management of severe acute malnutrition in children under two: A randomized controlled clinical trial in Bangladesh.Journal of global health · 2020Trial
- Use of multiple nursing interventions (cluster nursing) in ABO hemolytic disease of neonates and evaluation of its effect.The Journal of international medical research · 2020Trial
- Comparison of the Effectiveness of New Material Diapers versus Standard Diapers for the Prevention of Diaper Rash in Chinese Babies: A Double-Blinded, Randomized, Controlled, Cross-Over Study.BioMed research international · 2018Trial
- Mechanistic insights and clinical evidence of Helianthus annuus Linn. (Sunflower) seed oil for dermatological applications: A narrative review.Drug delivery and translational research · 2025Review
- Clinical Benefits of Basic Emollient Therapy for the Management of Patients With Xerosis Cutis.International journal of dermatology · 2025Review
- Nanotechnology in Infantile Hemangioma Management.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2025Article
- Skin Care Practices in Indian Newborns and Infants: Current Scenario.Pediatric health, medicine and therapeutics · 2025Review
- Skin Barrier Function in Neonates and Infants.Allergy, asthma & immunology research · 2025Review
- Article
- Bathing in Atopic Dermatitis in Pediatric Age: Why, How and When.Pediatric reports · 2024Review
- Effects of argan spinosa oil in the treatment of diaper dermatitis in infants and toddlers: A quasi-experimental study.Journal of Taibah University Medical Sciences · 2023Article
- Comparison of the Effects of Bathing and the Dry Technique on the Skin Condition of Early Neonates: A Prospective Observational Study.Annals of dermatology · 2023Article
- Coagulation signaling from amniotic fluid to fetal skin.Blood advances · 2022Article
- Experts' Consensus on the Use of Pimecrolimus in Atopic Dermatitis in China: A TCS-Sparing Practical Approach.Dermatology and therapy · 2022Article
- Skin Barrier Function in Infants: Update and Outlook.Pharmaceutics · 2022Review
- Development and Evaluation of an In Silico Dermal Absorption Model Relevant for Children.Pharmaceutics · 2022Article
- Wearable Sweat Loss Measuring Devices: From the Role of Sweat Loss to Advanced Mechanisms and Designs.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Review
- Article
- Pediatric contact allergens in the neonatal intensive care unit.Journal of perinatology : official journal of the California Perinatal Association · 2020Article
- A quantitative cross-sectional analysis of the melanin index in the skin of preterm newborns and its association with gestational age at birth.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2020Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infant skin is different from adult in structure, function, and composition. Despite these differences, the skin barrier is competent at birth in healthy, full-term neonates. The primary focus of this paper is on the developing skin barrier in healthy, full-term neonates and infants. Additionally, a brief discussion of the properties of the skin barrier in premature neonates and infants with abnormal skin conditions (i.e., atopic dermatitis and eczema) is included. As infant skin continues to mature through the first years of life, it is important that skin care products (e.g., cleansers and emollients) are formulated appropriately. Ideally, products that are used on infants should not interfere with skin surface pH or perturb the skin barrier. For cleansers, this can be achieved by choosing the right type of surfactant, by blending surfactants, or by blending hydrophobically-modified polymers (HMPs) with surfactants to increase product mildness. Similarly, choosing the right type of oil for emollients is important. Unlike some vegetable oils, mineral oil is more stable and is not subject to oxidation and hydrolysis. Although emollients can improve the skin barrier, more studies are needed to determine the potential long-term benefits of using emollients on healthy, full-term neonates and infants.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.