ArticleFrontiers in aging neuroscience2012
Characterizing cognitive aging of associative memory in animal models.
Article in Frontiers in aging neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed.
- Article
- Heterogenous effect of early adulthood stress on cognitive aging and synaptic function in the dentate gyrus.Frontiers in molecular neuroscience · 2024Article
- Neuroprotective efficacy of P7C3 compounds in primate hippocampus.Translational psychiatry · 2018Article
- The Role of Astrocytic Calcium Signaling in the Aged Prefrontal Cortex.Frontiers in cellular neuroscience · 2018Article
- Cognitive and behavioral evaluation of nutritional interventions in rodent models of brain aging and dementia.Clinical interventions in aging · 2017Review
- Distinct manifestations of executive dysfunction in aged rats.Neurobiology of aging · 2013Article
- Challenges and opportunities for characterizing cognitive aging across species.Frontiers in aging neuroscience · 2012Article
- Challenges and opportunities in characterizing cognitive aging across species.Frontiers in aging neuroscience · 2012Article
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Authors and funding
2 authors.
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Abstract
An overview is provided of the simple single-cue delay and trace eyeblink conditioning paradigms as techniques to assess associative learning and memory in the aged. We highlight and focus this review on the optimization of the parameter space of eyeblink conditioning designs in the aged to avoid and control for potential confounds that may arise when studying aged mammals. The need to examine the contribution of non-associative factors that can contribute to performance outcomes is emphasized, and how age-related changes in the central nervous system as well as peripheral sensory factors can potentially bias the interpretation of the data in the aged is discussed. The way in which slight alterations of the parameter space in the delay and trace eyeblink conditioning paradigms can lead to delayed but intact conditioning, rather than impaired performance in aged animals is also discussed. Overall, the eyeblink conditioning paradigm, when optimized for the age of the animal in the study, is an elegantly simple technique for assessment of associative learning and memory. When design caveats described above are taken into account, this important type of memory, with its well-defined neural substrates, should definitely be included in cognitive assessment batteries for the aged.
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